(E)-1-(2-chloro-5-(3-(methylamino)-3-oxo-1-phenylprop-1-en-1-yl)pyridin-1-ium-1-yl)-2-oxo-2-phenylethan-1-ide | 231618-73-8

• 英文名称: (E)-1-(2-chloro-5-(3-(methylamino)-3-oxo-1-phenylprop-1-en-1-yl)pyridin-1-ium-1-yl)-2-oxo-2-phenylethan-1-ide
• CAS: 231618-73-8
• 化学式: C₂₃H₁₉ClN₂O₂
• 分子量: 390.869
• InChiKey: HHDVPFRLTMWVAY-XSFVSMFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  氰胺 、 (E)-1-(2-chloro-5-(3-(methylamino)-3-oxo-1-phenylprop-1-en-1-yl)pyridin-1-ium-1-yl)-2-oxo-2-phenylethan-1-ide 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以40%的产率得到(E)-3-(2-amino-3-benzoylimidazo[1,2-a]pyridin-6-yl)-N-methyl-3-phenylprop-2-enamide
  参考文献：
  名称：

  Short synthesis and anti-rhinoviral activity of imidazo[1,2-a]pyridines: The effect of acyl groups at 3-position

  摘要：

  Various 2-amino-3-acyl-6-[(E)-1-phenyl-2-N-methylcarbamoylvinyl]-imidazo[1,2-a]pyridines, structurally related to Enviroxime were prepared to determine the effect of acyl groups on the anti-rhinoviral activity. A short and efficient means for the construction of the imidazo nucleus as well as biological evaluation of the final compounds are disclosed. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00193-6
• 作为产物：
  描述：

  2-氯-5-苯甲酰吡啶 在 双(三甲基硅烷基)氨基钾 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 生成 (E)-1-(2-chloro-5-(3-(methylamino)-3-oxo-1-phenylprop-1-en-1-yl)pyridin-1-ium-1-yl)-2-oxo-2-phenylethan-1-ide
  参考文献：
  名称：

  Short synthesis and anti-rhinoviral activity of imidazo[1,2-a]pyridines: The effect of acyl groups at 3-position

  摘要：

  Various 2-amino-3-acyl-6-[(E)-1-phenyl-2-N-methylcarbamoylvinyl]-imidazo[1,2-a]pyridines, structurally related to Enviroxime were prepared to determine the effect of acyl groups on the anti-rhinoviral activity. A short and efficient means for the construction of the imidazo nucleus as well as biological evaluation of the final compounds are disclosed. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00193-6