N-(6-azidocaproyl)deacetylcolchicine | 1391054-18-4

• 分子结构分类: 有机化合物 - 碳氢化合物衍生物 - 环庚三烯酮
• 英文名称: N-(6-azidocaproyl)deacetylcolchicine
• CAS: 1391054-18-4
• 化学式: C₂₆H₃₂N₄O₆
• 分子量: 496.563
• InChiKey: XREKZAWGYHYQFR-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.72
• 重原子数：
  36.0
• 可旋转键数：
  11.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  131.85
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  N-(6-azidocaproyl)deacetylcolchicine 、 2,4-di(4'-methoxybenzylamino)-6-[2'-(17-octadecynoyloxy)ethylamino]-1,3,5-triazine 在 magnesium ascorbate 、 copper(II) sulfate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 24.0h， 以64%的产率得到4-{16'-[3,5-di(4-methoxybenzylamino)-2,4,6-triazinylamino]ethyloxy-16'-oxohexadecanyl}-1-{6'-[(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)amino]-6'-oxohexyl}-1,2,3-triazole
  参考文献：
  名称：

  Synthesis and biological evaluation of novel anticancer bivalent colchicine–tubulizine hybrids

  摘要：

  A series of novel antimitotic hybrids were synthesized in good yields by linking of azide-containing colchicine congeners with acetylene-substituted tubulizine-type derivatives using copper-mediated 1,3-dipolar cycloaddition. Obtained compounds exhibit good cytotoxicity against HBL100 epithelial cell lines (IC50 = 0.599-2.93 mu M). Several newly synthesized compounds are the substoichiometric inhibitors of microtubule assembly (R = 0.41-0.78). The results highlight the importance of the length of spacer linking the tubulin binding ligands in heterodimeric molecules. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.05.072
• 作为产物：
  描述：

  秋水仙碱 在 4-二甲氨基吡啶 、 sodium methylate 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 、 乙腈 为溶剂， 反应 13.5h， 生成 N-(6-azidocaproyl)deacetylcolchicine
  参考文献：
  名称：

  Synthesis and biological evaluation of novel anticancer bivalent colchicine–tubulizine hybrids

  摘要：

  A series of novel antimitotic hybrids were synthesized in good yields by linking of azide-containing colchicine congeners with acetylene-substituted tubulizine-type derivatives using copper-mediated 1,3-dipolar cycloaddition. Obtained compounds exhibit good cytotoxicity against HBL100 epithelial cell lines (IC50 = 0.599-2.93 mu M). Several newly synthesized compounds are the substoichiometric inhibitors of microtubule assembly (R = 0.41-0.78). The results highlight the importance of the length of spacer linking the tubulin binding ligands in heterodimeric molecules. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.05.072