[Co(meso-tetra-(4-carboxyphenyl)-porphyrinato)(H2O)2](3-) | 60489-06-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [Co(meso-tetra-(4-carboxyphenyl)-porphyrinato)(H2O)2](3-)
• 英文别名: (H₂O)₂Co(III)-tetra(4-carboxyphenyl)porphyrin；(H₂O)₂CoTCPP；CoTCPP(H₂O)₂；[Co(TCPP)(H2O)2](3-)
• CAS: 60489-06-7
• 化学式: C₄₈H₂₈CoN₄O₁₀
• 分子量: 879.764
• InChiKey: ZSAMCWQIVCGGPP-NBICUONBSA-H

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  2,6-二甲基吡啶 、 [Co(meso-tetra-(4-carboxyphenyl)-porphyrinato)(H2O)2](3-) 以 aq. phosphate buffer 为溶剂， 生成 (H₂O)(2,6-dimethylpyridine)Co(III)tetra(4-carboxyphenyl)porphyrin
  参考文献：
  名称：

  Axial Coordination of Pyridine- and Imidazole-Based Drug Molecules to Co(III)-Tetra(4-Carboxyphenyl)porphyrin

  摘要：

  The substitutions of water molecules in the bisaqua axial complex of carboxy-substituted Co(III)-tetraphenylporphyrin by drug molecules based on amines and nitrogen-containing heterocycles are studied. The strongest bonded Co(III)-porphyrin complexes are formed with imidazole and pyridine derivatives. Depending on the nature and positions of functional groups in the heterocyclic moiety, imidazole- and pyridine- containing compounds can form either mono- or bis-axial complexes with Co(III) porphyrinate, these complexes having various stabilities. Aniline and quinuclidine drugs were found to react with Co(III) porphyrinate in aqueous media to produce only unstable monoaxial complexes.

  DOI：

  10.1134/s0036023618090061

文献信息

• Mechanistic Analysis of Reductive Nitrosylation on Water-Soluble Cobalt(III)-Porphyrins
  作者：Federico Roncaroli、Rudi van Eldik

  DOI：10.1021/ja0549906

  日期：2006.6.1

  The reactions of NO and/or NO2- with three water-soluble cobalt porphyrins [Co(III)(P)(H2O)2]n, where P = TPPS, TCPP, and TMPyP, were studied in detail. At pH < 3, the reaction with NO proceeds through a single reaction step. From the kinetic data and activation parameters, the [Co(III)(P)(NO)(H2O)]n complex is proposed to be the primary product of the reaction with NO. This complex reacts further

  详细研究了 NO 和/或 NO2- 与三种水溶性钴卟啉 [Co(III)(P)(H2O)2]n 的反应，其中 P = TPPS、TCPP 和 TMPyP。在 pH < 3 时，与 NO 的反应通过单个反应步骤进行。根据动力学数据和活化参数，[Co(III)(P)(NO)( )]n 络合物被认为是与 NO 反应的主要产物。该复合物通过球内电子转移反应与第二个 NO 分子进一步反应，生成最终产物 [Co(III)(P)(NO-)](n-1)。在 pH > 3 时，虽然也观察到单个反应步骤，但作为 NO 和 - 浓度函数的系统研究表明，两个反应步骤是有效的。首先， - 和 NO 竞争取代 [Co(III)(P)( )2]n 中的配位水，生成 [Co(III)(P)(NO)( )]n 和 [Co(III)(P) )( -)( )](n-1) 作为主要反应产物。在反应过