O¹-β-D-mannopyranosyl-D-mannitol | 1174302-49-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: O¹-β-D-mannopyranosyl-D-mannitol
• 英文别名: O¹-β-D-Mannopyranosyl-D-mannit；(2R,3R,4R,5R)-6-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,4,5-pentol
• CAS: 1174302-49-8
• 化学式: C₁₂H₂₄O₁₁
• 分子量: 344.316
• InChiKey: SERLAGPUMNYUCK-LUMRJFEFSA-N

物化性质

• 沸点：
  788.5±60.0 °C(Predicted)
• 密度：
  1.69±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -5.76
• 重原子数：
  23.0
• 可旋转键数：
  8.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  200.53
• 氢给体数：
  9.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  O¹-β-D-mannopyranosyl-D-mannitol 在 盐酸 作用下， 以 水 为溶剂， 反应 2.0h， 生成 D-甘露糖 、 甘露醇
  参考文献：
  名称：

  Acremomannolipin A, the potential calcium signal modulator with a characteristic glycolipid structure from the filamentous fungus Acremonium strictum

  摘要：

  By the newly developed assay method, the glycolipid Acremomannolipin A (1) was isolated from a filamentous fungus Acremonium strictum as a potential calcium signal modulator. The structure of 1 elucidated on the basis of intensive spectroscopic analyses as well as its degradation studies is quite unique: the D-mannopyranose is connected to D-mannitol through a beta-glycoside linkage; all the hydroxyls in the mannose are highly masked as peresters with aliphatic acids, and this moiety is made hydrophobic, whereas the mannitol part exhibits a highly hydrophilic property. The compound (1) showed the characteristic bioactivity property, enabling calcineurin deletion cells to grow in the presence of Cl-, which would be caused by calcium signal modulating. The activity was so potent as to exert the effect at a concentration of 200 nM. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.08.085
• 作为产物：
  描述：

  D-甘露糖 在 盐酸 、 potassium m-borate 、 水 作用下， 生成 O¹-β-D-mannopyranosyl-D-mannitol
  参考文献：
  名称：

  6.酸催化的L-阿拉伯糖和D-甘露糖的还原

  摘要：

  DOI：

  10.1039/jr9580000027