7-bromo-1,2,3,4-tetrahydro-benzo[4,5]imidazo[1,2-a]pyridine | 59504-41-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 7-bromo-1,2,3,4-tetrahydro-benzo[4,5]imidazo[1,2-a]pyridine
• 英文别名: 7-Brom-1,2,3,4-tetrahydro-pyridino<1,2-a>benzimidazol；7-Brom-1,2,3,4-tetrahydro-pyrido<1,2-a>benzimidazol；7-Bromo-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole
• CAS: 59504-41-5
• 化学式: C₁₁H₁₁BrN₂
• 分子量: 251.126
• InChiKey: CSJOKTDRTQAWMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  戊二醛 、 4-溴邻苯二胺 在 甲酸 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 8-bromo-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine 、 7-bromo-1,2,3,4-tetrahydro-benzo[4,5]imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Metal-free construction of tricyclic or tetracyclic compounds—acid-promoted synthesis of benzo[4,5]imidazo[2,1-a]isoindole and 1,2-dialkyl-2,3-dihydrobenzimidazoles

  摘要：

  An environmental friendly, efficient, and easy to operate strategy for synthesizing of benzo[4,5]imidazo [2,1-a]isoindole and 1,2-dialkyl-2,3-dihydrobenzimidazoles via acid-promoted coupling of dialdehyde and o-diaminobenzene under metal-free conditions is described. A series of products were generated in good yields under mild conditions. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.10.030

文献信息

• TETRAHYDRO-AZACARBOLINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USES THEREOF
  申请人：SURMAN Matthew D.

  公开号：US20120157460A1

  公开（公告）日：2012-06-21

  The present invention relates to tetrahydro-azacarboline derivatives of formula (I): having the substituents as described herein which are melanin-concentrating hormone (MCH-1) receptor antagonists. The present invention also relates to pharmaceutical compositions including these compounds, and methods of preparation and use thereof.

  本发明涉及式(I)的四氢-吖啶咔啉衍生物，其具有如本文所述的取代基，这些取代基是黑素浓缩激素（MCH-1）受体拮抗剂。本发明还涉及包括这些化合物的药物组合物，以及其制备和使用方法。
• SPIRODIAMINE-DIARYL KETOXIME DERIVATIVE
  申请人：Ando Makoto

  公开号：US20110071129A1

  公开（公告）日：2011-03-24

  [Problem] To provide a melanin concentrating hormone receptor antagonist useful as medicines for central system disorders, cardiovascular disorders, metabolic disorders. [Means for Resolution] Provided are compound of a formula (I): [wherein R 1 a and R 1 b each are a hydrogen atom, etc.; R 2 is a hydrogen atom, a C 1-6 alkyl, etc.; Ar 1 is a 6-membered aromatic carbocyclic group or a 6-membered aromatic nitrogen-containing heterocyclic group; Ar 2 is a group to be formed by removing two hydrogen atoms from a 6-membered aromatic carbon ring, a 6-membered aromatic nitrogen-containing hetero ring, etc.; Ar 3 is a mono- or bi-cyclic aromatic carbon ring or aromatic hetero ring; m 1 , m 2 , m 3 and m 4 each are independently 0, 1, 2, 3 or 4, provided that the total of m 1 and m 2 is from 2 to 6, the total of m 3 and m 4 is from 2 to 6]. The compounds are useful as medicines for central system disorders, cardiovascular disorders, metabolic disorders.

  [问题] 提供一种黑色素浓集激素受体拮抗剂，可用作中枢系统疾病、心血管疾病和代谢性疾病的药物。[解决方案] 提供了一种公式（I）的化合物：[其中R1a和R1b分别是氢原子等；R2是氢原子、C1-6烷基等；Ar1是6元芳香碳环基或6元芳香氮杂环基；Ar2是从6元芳香碳环、6元芳香氮杂环等中去除两个氢原子形成的基团；Ar3是单环或双环芳香碳环或芳香杂环；m1、m2、m3和m4各自独立地为0、1、2、3或4，前提是m1和m2的总和为2到6，m3和m4的总和为2到6]。这些化合物可用作中枢系统疾病、心血管疾病和代谢性疾病的药物。
• EP2301936A1
  申请人：——

  公开号：EP2301936A1

  公开（公告）日：2011-03-30
• Metal-free construction of tricyclic or tetracyclic compounds—acid-promoted synthesis of benzo[4,5]imidazo[2,1-a]isoindole and 1,2-dialkyl-2,3-dihydrobenzimidazoles
  作者：Jinying Chen、Jinpeng Qu、Yuanqing Zhang、Yongxin Chen、Na Liu、Baohua Chen

  DOI：10.1016/j.tet.2012.10.030

  日期：2013.1

  An environmental friendly, efficient, and easy to operate strategy for synthesizing of benzo[4,5]imidazo [2,1-a]isoindole and 1,2-dialkyl-2,3-dihydrobenzimidazoles via acid-promoted coupling of dialdehyde and o-diaminobenzene under metal-free conditions is described. A series of products were generated in good yields under mild conditions. (C) 2012 Elsevier Ltd. All rights reserved.