8-bromo-2-(dichloromethyl)-Imidazo[1,2-a]pyridine | 1201630-35-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 8-bromo-2-(dichloromethyl)-Imidazo[1,2-a]pyridine
• 英文别名: 8-bromo-2-(dichloromethyl)imidazo[1,2-a]pyridine
• CAS: 1201630-35-4
• 化学式: C₈H₅BrCl₂N₂
• 分子量: 279.951
• InChiKey: MEIKHJFXARBLAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  17.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  8-bromo-2-(dichloromethyl)-Imidazo[1,2-a]pyridine 在 水 、 calcium carbonate 作用下， 反应 1.5h， 以91%的产率得到8-溴-咪唑并[1,2-a]吡啶-2-甲醛
  参考文献：
  名称：

  Imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1

  摘要：

  Synthesis of several novel imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV are described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity and pharmacokinetics are highlighted. Several compounds with low nanomolar anti-HIV activity and oral bioavailability are described. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.056
• 作为产物：
  描述：

  2-氨基-3-溴吡啶 、 1,1,3-三氯丙酮 以 乙二醇二甲醚 为溶剂， 反应 15.0h， 以45%的产率得到8-bromo-2-(dichloromethyl)-Imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1

  摘要：

  Synthesis of several novel imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV are described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity and pharmacokinetics are highlighted. Several compounds with low nanomolar anti-HIV activity and oral bioavailability are described. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.056

文献信息

• Imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1
  作者：Kristjan S. Gudmundsson、Sharon D. Boggs、John G. Catalano、Angilique Svolto、Andrew Spaltenstein、Michael Thomson、Pat Wheelan、Stephen Jenkinson

  DOI：10.1016/j.bmcl.2009.09.056

  日期：2009.11

  Synthesis of several novel imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV are described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity and pharmacokinetics are highlighted. Several compounds with low nanomolar anti-HIV activity and oral bioavailability are described. (C) 2009 Elsevier Ltd. All rights reserved.