6-oxo-3-phenyl-5,6-dihydropyridazine-1(4H)-carbohydrazide | 1215300-75-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-oxo-3-phenyl-5,6-dihydropyridazine-1(4H)-carbohydrazide
• 英文别名: 6-Oxo-3-phenyl-4,5-dihydropyridazine-1-carbohydrazide
• CAS: 1215300-75-6
• 化学式: C₁₁H₁₂N₄O₂
• 分子量: 232.242
• InChiKey: AKOGIWUYDXLJTH-UHFFFAOYSA-N

物化性质

• 熔点：
  166-168 °C(Solv: ethanol (64-17-5))
• 密度：
  1.41±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  87.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-oxo-3-phenyl-5,6-dihydropyridazine-1(4H)-carbohydrazide 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 2-[4-(4-methylphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]-6-phenyl-4,5-dihydropyridazin-3-one
  参考文献：
  名称：

  Triazole incorporated pyridazinones as a new class of antihypertensive agents: Design, synthesis and in vivo screening

  摘要：

  A number of 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were designed and synthesized by a sequence of reactions starting from respective aryl hydrocarbons. The final compounds (4a-4u) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 4e, 4i and 4k showed appreciable antihypertensive activity comparable with that of standard hydralazine and propranolol. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.028
• 作为产物：
  描述：

  碳酰肼 、 3-苯丙烯溴酸酯 以 乙醇 为溶剂， 生成 6-oxo-3-phenyl-5,6-dihydropyridazine-1(4H)-carbohydrazide
  参考文献：
  名称：

  Triazole incorporated pyridazinones as a new class of antihypertensive agents: Design, synthesis and in vivo screening

  摘要：

  A number of 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were designed and synthesized by a sequence of reactions starting from respective aryl hydrocarbons. The final compounds (4a-4u) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 4e, 4i and 4k showed appreciable antihypertensive activity comparable with that of standard hydralazine and propranolol. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.028

文献信息

• SYNTHESIS, CHARACTERIZATION AND ANTIHYPERTENSIVE ACTIVITY OF SOME NEW SUBSTITUTED PYRIDAZINE DERIVATIVES
  作者：RAVINESH MISHRA、ANEES A SIDDIQUI、ASIF HUSAIN、MOHD RASHID、ATISH PRAKASH、MUKUL TAILANG、MUNEESH KUMAR、NEETI SRIVASTAVA

  DOI：10.4067/s0717-97072011000400006

  日期：——

  Some new 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by a sequence of reactions starting from respective aryl hydrocarbons. The final compounds (4a-i) were screened for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 4e and 4i showed appreciable antihypertensive

  一些新的6-（取代的苯基）-2-（4-取代的苯基-5-thioxo-4,5-二氢-1H-1,2,4-三唑-3-基）-4,5-二氢哒嗪-3（通过从各自的芳基烃开始的一系列反应合成2H）-一衍生物。使用尾套法通过无创方法筛选最终化合物（4a-i）的抗高血压活性。化合物4e和4i显示出明显的抗高血压活性。