2-hydroxy-1-phenyl-3-pentanone | 99309-91-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-1-phenyl-3-pentanone
• 英文别名: hazakacin；2-hydroxy-1-phenyl-pentan-3-one；2-Hydroxy-1-phenyl-pentan-3-on；2-hydroxy-1-phenylpentan-3-one
• CAS: 99309-91-8
• 化学式: C₁₁H₁₄O₂
• 分子量: 178.231
• InChiKey: BLINVGVCILRBBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,2-epoxy-1-phenyl-pentan-3-one 在 乙醇 、 palladium nickel 作用下， 生成 2-hydroxy-1-phenyl-3-pentanone
  参考文献：
  名称：

  Temnikowa; Kropatschew, Zhurnal Obshchei Khimii, 1951, vol. 21, p. 501,504; engl. Ausg. S. 555, 557

  摘要：

  DOI：

文献信息

• Addition of organomagnesium reagents to cyanohydrin--silyl ethers: An efficient and flexible synthesis of unsymmetrically substituted acyloins
  作者：Melvyn Gill、Milton J Kiefel、Deborah A Lally

  DOI：10.1016/s0040-4039(00)84415-9

  日期：1986.1

  Acyloins are prepared in high yields reaction between Grignard reagents and -trimethylsilyl ethers of aldehyde cyanohydrins: the method is particularly useful for the preparation of discrete acyloins in which the substituents are unsymmetrically disposed about the α-hydroxyketone moiety.

  醛缩蛋白是通过格氏试剂与醛氰醇的-三甲基甲硅烷基醚之间的高收率反应制备的：该方法特别适用于制备其中取代基在α-羟基酮部分周围不对称分布的离散酰基缩醛。
• Compositions and Methods for Fermentation of Biomass
  申请人：Parekh Sarad

  公开号：US20100268000A1

  公开（公告）日：2010-10-21

  In one aspect, this invention relates to production of useful fermentation end-products from biomass through simultaneous hydrolysis and fermentation by a microorganism, such as Clostridium phytofermentans . The invention also relates to the development of a process for efficient pretreatment and conversion of lignocellulosic biomass to end-products with high conversion efficiency (yield). In another aspect, methods for producing a fermentation end-product by fermenting hexose (C6) and pentose (C5) sugars with a microorganism, such as Clostridium phytofermentans are disclosed herein.

  在一个方面，这项发明涉及通过微生物（如植物发酵槽菌）的同时水解和发酵，从生物质中生产有用的发酵终产物。该发明还涉及开发一种高效预处理和转化木质纤维素生物质为高转化效率（产率）的终产物的过程。在另一个方面，本文介绍了利用微生物（如植物发酵槽菌）发酵己糖（C6）和戊糖（C5）糖产生发酵终产物的方法。
• BIOFUEL PRODUCTION
  申请人：Yoshikuni Yasuo

  公开号：US20090139134A1

  公开（公告）日：2009-06-04

  Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity chemical enriched, refinery-produced petroleum products are also provided, as well as methods for producing the same.

  提供了用于将多糖转化为适当的单糖或寡糖的方法、酶、重组微生物和微生物系统，例如从生物质中提取的多糖。同时提供了将适当的单糖或寡糖转化为商品化学品，如生物燃料的方法。本文描述的方法生产的商品化学品也提供了。此外，还提供了商品化学品富集的、精炼生产的石油产品，以及生产这些产品的方法。
• METHODS AND COMPOSITIONS FOR PRODUCING CHEMICAL PRODUCTS FROM C. PHYTOFERMENTANS
  申请人：Schmalisch Matthias

  公开号：US20110183382A1

  公开（公告）日：2011-07-28

  This invention provides systems and methods for the production of compounds by C. phytofermentans. C. phytofermentans is genetically-engineered for hydrolysis and fermentation of carbonaceous biomass to synthesize compounds of commercial value.

  这项发明提供了通过C. phytofermentans生产化合物的系统和方法。C. phytofermentans被基因工程化，用于水解和发酵碳质生物质以合成具有商业价值的化合物。
• Synthesis of acyloin natural products by Mukaiyama hydration
  作者：Michael Ricca、Wei Zhang、Jiaqi Li、Thomas Fellowes、Jonathan M. White、Paul S. Donnelly、Mark A. Rizzacasa

  DOI：10.1039/d2ob00651k

  日期：——

  The acyloin natural products are a family of bioactive compounds isolated from fungi and myxobacteria. The total synthesis of 7 members of the acyloin family was achieved via a HWE reaction followed by Mukaiyama–Isayama hydration, using novel Co(II) and Co(III) Schiff base SALPN complexes as catalysts for the key enone hydration step. Furthermore, we have shown that a mild acyloin rearrangement is

  acyloin 天然产物是从真菌和粘细菌中分离出来的一类生物活性化合物。使用新型 Co( II ) 和 Co( III ) 席夫碱 SALPN 配合物作为关键烯酮水合步骤的催化剂，通过HWE 反应和 Mukaiyama-ISAyama 水合实现了 acyloin 家族 7 个成员的全合成。此外，我们已经证明，在向山水合条件下，温和的 acyloin 重排是可能的，这对于这种方法的成功至关重要。