N-(2-chloro-5-nitrophenyl)-4-hexylbenzamide | 1208255-48-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-chloro-5-nitrophenyl)-4-hexylbenzamide
• CAS: 1208255-48-4
• 化学式: C₁₉H₂₁ClN₂O₃
• 分子量: 360.84
• InChiKey: TWXMIVPOYBQWNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-己基苯甲酸 、 2-氯-5-硝基苯胺 在 EDC-polymer 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以55%的产率得到N-(2-chloro-5-nitrophenyl)-4-hexylbenzamide
  参考文献：
  名称：

  Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis

  摘要：

  A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide 17 which exhibited low micromolar inhibitory potency against T. brucei and selectivity towards both malaria and mammalian cells. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.11.022

文献信息

• Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis
  作者：Jong Yeon Hwang、David Smithson、Michele Connelly、Julie Maier、Fangyi Zhu、Kiplin R. Guy

  DOI：10.1016/j.bmcl.2009.11.022

  日期：2010.1

  A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide 17 which exhibited low micromolar inhibitory potency against T. brucei and selectivity towards both malaria and mammalian cells. (C) 2009 Elsevier Ltd. All rights reserved.