3'-Hydroxyxanthyletin

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3'-Hydroxyxanthyletin
• 英文别名: 3-hydroxy-2,2-dimethylpyrano[3,2-g]chromen-8-one
• 化学式: C₁₄H₁₂O₄
• 分子量: 244.24
• InChiKey: FMYNVGVODWZNCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NEW COMPOUND FOR INHIBITING BINDING BETWEEN DX2 PROTEIN AND P14/ARF PROTEIN, AND PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING CANCER DISEASE CONTAINING SAME AS EFFECTIVE INGREDIENT
  申请人：PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION

  公开号：US20170129904A1

  公开（公告）日：2017-05-11

  Disclosed is a new compound that inhibits binding between a DX2 protein and a p14/ARF protein, a pharmaceutical composition including the new compound as an effective component for treating or preventing a cancer disease, an anticancer adjuvant for improving an anticancer effect of a drug-resistant anticancer drug, and a composition including an AIMP2-DX2 protein or a fragment thereof for diagnosing lung cancer.

  披露了一种新化合物，该化合物抑制了DX2蛋白与p14/ARF蛋白之间的结合，包括该新化合物作为治疗或预防癌症疾病的有效成分的药物组合物，用于提高耐药抗癌药物的抗癌效果的抗癌辅助剂，以及包括AIMP2-DX2蛋白或其片段的组合物，用于诊断肺癌。
• Compound for inhibiting binding between DX2 protein and P14/ARF protein, and pharmaceutical composition for treating or preventing cancer disease containing same as effective ingredient
  申请人：PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION

  公开号：US10072021B2

  公开（公告）日：2018-09-11

  Disclosed is a new compound that inhibits binding between a DX2 protein and a p14/ARF protein, a pharmaceutical composition including the new compound as an effective component for treating or preventing a cancer disease, an anticancer adjuvant for improving an anticancer effect of a drug-resistant anticancer drug, and a composition including an AIMP2-DX2 protein or a fragment thereof for diagnosing lung cancer.

  公开了一种抑制 DX2 蛋白和 p14/ARF 蛋白之间结合的新化合物、一种包括新化合物作为有效成分用于治疗或预防癌症疾病的药物组合物、一种用于改善耐药抗癌药物抗癌效果的抗癌辅助剂，以及一种包括 AIMP2-DX2 蛋白或其片段用于诊断肺癌的组合物。
• Compound for inhibiting binding between DX2 protein and p14/ARF protein, and pharmaceutical composition for treating or preventing cancer disease containing same as effective ingredient
  申请人：PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION

  公开号：US10280178B2

  公开（公告）日：2019-05-07

  Disclosed is a new compound that inhibits binding between a DX2 protein and a p14/ARF protein, a pharmaceutical composition including the new compound as an effective component for treating or preventing a cancer disease, an anticancer adjuvant for improving an anticancer effect of a drug-resistant anticancer drug, and a composition including an AIMP2-DX2 protein or a fragment thereof for diagnosing lung cancer.

  公开了一种抑制 DX2 蛋白和 p14/ARF 蛋白之间结合的新化合物、一种包括新化合物作为有效成分用于治疗或预防癌症疾病的药物组合物、一种用于改善耐药抗癌药物抗癌效果的抗癌辅助剂，以及一种包括 AIMP2-DX2 蛋白或其片段用于诊断肺癌的组合物。
• USE OF A COMPOSITION COMPRISING AN AIMP2-DX2 PROTEIN FOR DIAGNOSING LUNG CANCER
  申请人：Pusan National University Industry-University Cooperation Foundation

  公开号：EP3605102B1

  公开（公告）日：2021-06-16