5-(4',5'-Dihydroxy-pentyl)-uracil | 39657-66-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-(4',5'-Dihydroxy-pentyl)-uracil
• 英文别名: 5-(4,5-dihydroxy-pentyl)-1H-pyrimidine-2,4-dione；5-(4,5-Dihydroxypentyl)uracil；5-(4,5-dihydroxypentyl)-1H-pyrimidine-2,4-dione
• CAS: 39657-66-4
• 化学式: C₉H₁₄N₂O₄
• 分子量: 214.221
• InChiKey: AMIOJPURYLGJEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  98.7
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• In vivo labelling of polynucleotide sequences
  申请人：ENZO BIOCHEM, INC.

  公开号：EP0133473A2

  公开（公告）日：1985-02-27

  in vivo labelled polynucleotides, processes for in vivo labelling of polynucleotides, and detection methods and kits characterized by those labelled polynucleotides. In in vivo on biologically-labelled polynucleotides of this invention are useful in the detection of various analytes and in other laboratory, industrial and medical applications.

  体内标记的多核苷酸、体内标记多核苷酸的工艺以及以这些标记的多核苷酸为特征的检测方法和试剂盒。 本发明的体内生物标记多核苷酸可用于检测各种分析物以及其他实验室、工业和医疗应用。
• A method of inducing antitumor immunocytes, and a process for producing antitumor immunocytes and antitumor immunocytes produced by the process
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0147689A2

  公开（公告）日：1985-07-10

  A method of inducing antitumor immunocytes which is simple in operation and suitable for inducing antitumor immunocytes having not only excellent cytotoxic activity against tumor cells but also high safety, which method comprises contacting leucocytes with an insoluble, antitumor immunocyte-inducing material capable of linking with T cells, said antitumor immunocyte-inducing material comprising an insoluble carrier and a ligand linked therewith. The induced antitumor immunocytes can be simply separated in substantially ligand-free form from the insoluble, antitumor immunocyte-inducing material. The obtained antitumor immunocytes have not only excellent cytotoxic activity against tumor cells but also high safety.

  一种诱导抗肿瘤免疫细胞的方法，该方法操作简单，适用于诱导抗肿瘤免疫细胞，不仅对肿瘤细胞具有优异的细胞毒活性，而且安全性高，该方法包括使白细胞与不溶性的、能与 T 细胞连接的抗肿瘤免疫细胞诱导材料接触，所述抗肿瘤免疫细胞诱导材料包括不溶性载体和与之连接的配体。 可以简单地将诱导的抗肿瘤免疫细胞以基本上不含配体的形式从不溶性的抗肿瘤免疫细胞诱导材料中分离出来。 获得的抗肿瘤免疫细胞不仅对肿瘤细胞具有优异的细胞毒活性，而且安全性高。
• NUCLEOSIDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
  申请人：RIKAGAKU KENKYUSHO

  公开号：EP0311694A1

  公开（公告）日：1989-04-19

  The present invention relates to dideoxynucleoside derivatives useful as antiviral agents, intermediates useful for synthesizing them and synthetic processes thereof. The processes of the present invention are characterized in that a mesyl group, a tosyl group or a trifluoromethanesulfonyl group is selectively introduced into the ribose 3'-position of the various nucleoside derivatives in which the base component, the ribose 2'-position, and 5'- position are protected and then treated with a base and a reducing agent to produce effectively intermediates useful for synthesizing dideoxynucleoside derivatives. By employing this process, various novel intermediadtes and dideoxynucleoside derivatives can be obtained. Further, the present invention provides the process for synthesizing the intermediates useful for synthesizing dideoxynucleoside derivatives, which comprises reacting an alkaline compound with nucleoside derivatives in which the base component, the ribose 2'-position and the ribose 5'-position are protected with pivaloyl groups and the ribose 3'-position is protected with a mesyl group, a tosyl group or a trifluoromethanesulfonyl group to selectively eliminate only the pivaloyl group of the base to thereby produce the intermediate.

  本发明涉及用作抗病毒剂的二脱氧核苷衍生物、用于合成它们的中间体及其合成工艺。 本发明工艺的特点是，在碱基成分、核糖 2'- 位和 5'- 位受到保护的各种核苷衍生物的核糖 3'- 位上，选择性地引入一个甲磺酰基、一个甲苯磺酰基或一个三氟甲磺酰基，然后用碱和还原剂处理，从而有效地生成用于合成双脱氧核苷衍生物的中间体。采用这种工艺可以获得各种新型中间体和二脱氧核苷衍生物。 此外，本发明还提供了用于合成二脱氧核苷衍生物的中间体的合成工艺，该工艺包括将碱性化合物与核苷衍生物反应，其中碱基成分、核糖 2'- 位和核糖 5'- 位被新戊酰基保护，核糖 3'- 位被甲磺酰基、甲苯磺酰基或三氟甲磺酰基保护，以选择性地只消除碱基的新戊酰基，从而生成中间体。
• US4839290A
  申请人：——

  公开号：US4839290A

  公开（公告）日：1989-06-13
• US4987065A
  申请人：——

  公开号：US4987065A

  公开（公告）日：1991-01-22