4a,4b-dimethyl-hexahydro-cyclobuta[1,2-d;4,3-d']dipyrimidine-2,4,5,7-tetraone | 14122-25-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4a,4b-dimethyl-hexahydro-cyclobuta[1,2-d;4,3-d']dipyrimidine-2,4,5,7-tetraone
• 英文别名: Dimethylthymin-Dimer (syn)；Thymine dimer；7,8-dimethyl-3,5,10,12-tetrazatricyclo[6.4.0.02,7]dodecane-4,6,9,11-tetrone
• CAS: 14122-25-9；136779-51-6
• 化学式: C₁₀H₁₂N₄O₄
• 分子量: 252.23
• InChiKey: ASJWEHCPLGMOJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  胸腺嘧啶 以 水 为溶剂， 反应 6.0h， 生成 4a,4b-dimethyl-hexahydro-cyclobuta[1,2-d;4,3-d']dipyrimidine-2,4,5,7-tetraone
  参考文献：
  名称：

  用于通过氢-氘交换进行局部环境传感的炔烃标记拉曼探针

  摘要：

  炔烃标记的拉曼探针已显示出对小生物分子进行无创和灵敏可视化以了解它们在活细胞中的功能作用的巨大希望。然而，炔烃感知超越成像的细胞环境的潜力仍有待进一步探索。在这里，我们报告了一种通过末端炔烃（称为炔烃-HDX）的氢-氘交换（HDX）进行基于拉曼成像的局部环境传感的一般策略。我们首先在多个拉曼探针中证明，炔基氢的氘化会导致炔烃拉曼峰发生显着位移约 130 cm –1，提供适合基于成像的高特异性分析的可分辨信号。我们的分析推导和实验表征随后都确定 HDX 动力学与炔烃 p Ka s 和环境 pD呈线性比例。在验证了该策略的定量性质后，我们将炔烃-HDX 应用于感测局部化学和细胞环境。我们确定炔烃-HDX 对各种 DNA 结构表现出高灵敏度，并展示了原位检测 DNA 结构变化的能力免受紫外线引起的伤害。我们进一步表明，这种策略也适用于解决活细胞中细微的 pD 变化。总而言之，我们的工作为利用炔烃-HDX

  DOI：

  10.1021/jacs.2c01991

文献信息

• [EN] AGENTS THAT PREVENT OR REPAIR SKIN DAMAGE<br/>[FR] AGENTS PRÉVENANT OU RÉPARANT DES LÉSIONS CUTANÉES
  申请人：UNIV MINNESOTA

  公开号：WO2013106728A1

  公开（公告）日：2013-07-18

  The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides dermatological compositions comprising a compound of formula I or mixtures of one or more compounds of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for protecting skin or DNA from photodamage or repairing photodamaged skin or DNA.

  该发明提供了如下的I式化合物或其盐，如本文所述。该发明还提供了包括I式化合物或一种或多种I式化合物的混合物的皮肤科学组合物，用于制备I式化合物的方法，用于制备I式化合物的有用中间体，以及用于保护皮肤或DNA免受光损伤或修复光损伤皮肤或DNA的治疗方法。
• [EN] SUNLESS TANNING COMPOUNDS AND COMPOSITIONS<br/>[FR] COMPOSÉS ET COMPOSITIONS DE BRONZAGE SANS SOLEIL
  申请人：UNIV MINNESOTA

  公开号：WO2015003095A1

  公开（公告）日：2015-01-08

  The invention provides sunless tanning compositions comprising a compounds of formula (I): or a salt thereof as described herein as well as methods for tanning mammalian skin by contacting the skin with the compounds of formula (I) or compositions comprising compounds of formula (I).

  该发明提供了一种无日晒的美黑组合物，包括本文所述的化合物(I)的盐，以及通过将皮肤与化合物(I)或含有化合物(I)的组合物接触来晒黑哺乳动物皮肤的方法。
• AGENTS THAT PREVENT OR REPAIR SKIN DAMAGE
  申请人：Regents of the University of Minnesota

  公开号：US20140350036A1

  公开（公告）日：2014-11-27

  The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides dermatological compositions comprising a compound of formula I or mixtures of one or more compounds of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for protecting skin or DNA from photodamage or repairing photodamaged skin or DNA.

  本发明提供了以下式I的化合物：或其盐，如本文所述。本发明还提供了包含式I化合物或一种或多种式I化合物的混合物的皮肤学组合物，制备式I化合物的方法，用于制备式I化合物的中间体以及保护皮肤或DNA免受光损伤或修复光损伤皮肤或DNA的治疗方法。
• Acrylate coating compositions comprising a UV light cleavable cross-linking agent
  申请人：Monash University

  公开号：US11078368B2

  公开（公告）日：2021-08-03

  The present disclosure provides a coating composition for forming a coating that at least partially mobilizes in response to UV light, the composition comprising a monomer selected from acrylates, methacrylates and mixtures thereof, a cross-linking agent comprising two sub-units covalently bonded together, each sub-unit comprising an unsaturated group which is co-polymerisable with the monomer, wherein the two sub-units are adapted to dissociate in response to irradiation by UV light. The cross-linking agent may be present in the coating composition in an amount of less than 15 mol % of the total of the monomer and cross-linking agent.

  本公开提供了一种涂料组合物，用于形成在紫外线照射下至少部分移动的涂层，该组合物包括选自丙烯酸酯、甲基丙烯酸酯及其混合物的单体、交联剂，交联剂包括共价键合在一起的两个亚单元，每个亚单元包括可与单体共聚的不饱和基团，其中两个亚单元适于在紫外线照射下解离。交联剂在涂层组合物中的含量可低于单体和交联剂总量的 15 摩尔%。
• SUNLESS TANNING COMPOUNDS AND COMPOSITIONS
  申请人：REGENTS OF THE UNIVERSITY OF MINNESOTA

  公开号：US20170000712A1

  公开（公告）日：2017-01-05

  The invention provides sunless tanning compositions comprising a compounds of formula (I): or a salt thereof as described herein as well as methods for tanning mammalian skin by contacting the skin with the compounds of formula (I) or compositions comprising compounds of formula (I).