terremide C | 1443332-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: terremide C
• 英文别名: Terremide C；methyl 3,4,5-trimethoxy-2-(4-oxo-2-pyridin-3-ylquinazolin-3-yl)benzoate
• CAS: 1443332-60-2
• 化学式: C₂₄H₂₁N₃O₆
• 分子量: 447.447
• InChiKey: AVVXZSFAPUSQEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  99.6
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  methyl 3,4,5-trimethoxy-2-((2-((3-pyridinylcarbonyl)amino)benzoyl)amino)benzoate 以 吡啶 为溶剂， 反应 8.0h， 生成 terremide C
  参考文献：
  名称：

  Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162

  摘要：

  A new cytotoxic and antiviral cyclic tetrapeptide, asperterrestide A(1), a new alkaloid, terremide C (2), and a new aromatic butenolide, aspernolide E (A), together with 10 known compounds were isolated from the fermentation broth of the marine-derived fungus Aspergillus terreus SCSGAF0162:. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of 1 was determined by the Mosher ester technique, and analysis of the acid hydrolysates using a chiral, phase HPLC column. Compound 1 contains a rare 3-OH-N-CH3-Phe residue and showed cytotoxicity against U937 and MOLT4 human carcinoma cell lines and inhibitory effects on influenza virus strains H1N1 and H3N2.

  DOI：

  10.1021/np300897v