申请人：SESHA Ramesh
公开号：US20120046272A1
公开（公告）日：2012-02-23
The present invention describes a series of therapeutically active compounds of formula I,
X—Y—Z (I)
that are useful for treating a disorder in a mammal. In the formula I, X and Z, which may be same or different, are independently selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted heterocyclic group or substituted or unsubstituted heterocyclylalkyl; and Y is a linker selected from —O—, —S—, —NH—, —(CH
2
)
n
—, —CO—, —CONR
a
—, —NR
a
CO—, —NR
a
COO—, —COO—, —CONR
a
CO—, —CONR
a
COO— and —COOCOO—. The compounds are useful to treat neurodegenerative disorders, depression, Alzheimer's disease, cognitive disorders, motor disorders, Parkinson's disease, drug addiction, behavioral disorders, inflammatory disorders, stomach disorders, cancers, acute pain, chronic pain and recurrent pain.
本发明描述了一系列具有治疗活性的化合物，其
化学式为I，X—Y—Z (I)，适用于治疗哺乳动物中的某种疾病。在
化学式I中，X和Z，可以相同也可以不同，独立地选择自取代或未取代的烷基、取代或未取代的烯基、取代或未取代的环烷基、取代或未取代的环烷基烷基、取代或未取代的芳基、取代或未取代的芳基烷基、取代或未取代的杂芳基、取代或未取代的杂芳基烷基、取代或未取代的杂环基团或取代或未取代的杂环烷基；Y是从—O—、—S—、—NH—、—(
CH2)n—、—CO—、—CONRa—、—NRaCO—、—NRaCOO—、—COO—、—CONRaCO—、—CONRaCOO—和—COOCOO—中选择的连接基团。这些化合物适用于治疗神经退行性疾病、抑郁症、阿尔茨海默病、认知障碍、运动障碍、帕
金森病、药物成瘾、行为障碍、炎症性疾病、胃病、癌症、急性疼痛、慢性疼痛和复发性疼痛。
![6,14-Ethenomorphinan-7-methanol, 4,5-epoxy-3-hydroxy-6-methoxy-alpha,17-dimethyl-alpha-propyl-, [5alpha,7alpha(R)]-化学式](data:image/svg+xml;base64,<?xml version="1.0" encoding="UTF-8"?>
<svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" width="300" height="300" viewBox="0 0 300 300">
<defs>
<g>
<g id="glyph-0-0">
<path d="M 0.78125 2.78125 L 0.78125 -11.09375 L 8.65625 -11.09375 L 8.65625 2.78125 Z M 1.671875 1.90625 L 7.78125 1.90625 L 7.78125 -10.203125 L 1.671875 -10.203125 Z M 1.671875 1.90625 "/>
</g>
<g id="glyph-0-1">
<path d="M 10.140625 -10.59375 L 10.140625 -8.953125 C 9.609375 -9.441406 9.046875 -9.804688 8.453125 -10.046875 C 7.867188 -10.285156 7.242188 -10.40625 6.578125 -10.40625 C 5.265625 -10.40625 4.257812 -10.003906 3.5625 -9.203125 C 2.863281 -8.398438 2.515625 -7.238281 2.515625 -5.71875 C 2.515625 -4.207031 2.863281 -3.050781 3.5625 -2.25 C 4.257812 -1.445312 5.265625 -1.046875 6.578125 -1.046875 C 7.242188 -1.046875 7.867188 -1.164062 8.453125 -1.40625 C 9.046875 -1.65625 9.609375 -2.019531 10.140625 -2.5 L 10.140625 -0.890625 C 9.585938 -0.515625 9.007812 -0.234375 8.40625 -0.046875 C 7.800781 0.128906 7.160156 0.21875 6.484375 0.21875 C 4.742188 0.21875 3.375 -0.3125 2.375 -1.375 C 1.382812 -2.4375 0.890625 -3.882812 0.890625 -5.71875 C 0.890625 -7.5625 1.382812 -9.015625 2.375 -10.078125 C 3.375 -11.140625 4.742188 -11.671875 6.484375 -11.671875 C 7.171875 -11.671875 7.816406 -11.578125 8.421875 -11.390625 C 9.023438 -11.210938 9.597656 -10.945312 10.140625 -10.59375 Z M 10.140625 -10.59375 "/>
</g>
<g id="glyph-0-2">
<path d="M 1.546875 -11.46875 L 3.09375 -11.46875 L 3.09375 -6.765625 L 8.734375 -6.765625 L 8.734375 -11.46875 L 10.28125 -11.46875 L 10.28125 0 L 8.734375 0 L 8.734375 -5.46875 L 3.09375 -5.46875 L 3.09375 0 L 1.546875 0 Z M 1.546875 -11.46875 "/>
</g>
<g id="glyph-0-3">
<path d="M 1.546875 -11.46875 L 3.640625 -11.46875 L 8.71875 -1.875 L 8.71875 -11.46875 L 10.21875 -11.46875 L 10.21875 0 L 8.140625 0 L 3.046875 -9.59375 L 3.046875 0 L 1.546875 0 Z M 1.546875 -11.46875 "/>
</g>
<g id="glyph-0-4">
<path d="M 6.203125 -10.421875 C 5.078125 -10.421875 4.179688 -10 3.515625 -9.15625 C 2.847656 -8.3125 2.515625 -7.164062 2.515625 -5.71875 C 2.515625 -4.28125 2.847656 -3.140625 3.515625 -2.296875 C 4.179688 -1.453125 5.078125 -1.03125 6.203125 -1.03125 C 7.328125 -1.03125 8.21875 -1.453125 8.875 -2.296875 C 9.53125 -3.140625 9.859375 -4.28125 9.859375 -5.71875 C 9.859375 -7.164062 9.53125 -8.3125 8.875 -9.15625 C 8.21875 -10 7.328125 -10.421875 6.203125 -10.421875 Z M 6.203125 -11.671875 C 7.804688 -11.671875 9.085938 -11.128906 10.046875 -10.046875 C 11.015625 -8.972656 11.5 -7.53125 11.5 -5.71875 C 11.5 -3.914062 11.015625 -2.472656 10.046875 -1.390625 C 9.085938 -0.316406 7.804688 0.21875 6.203125 0.21875 C 4.585938 0.21875 3.296875 -0.316406 2.328125 -1.390625 C 1.367188 -2.460938 0.890625 -3.90625 0.890625 -5.71875 C 0.890625 -7.53125 1.367188 -8.972656 2.328125 -10.046875 C 3.296875 -11.128906 4.585938 -11.671875 6.203125 -11.671875 Z M 6.203125 -11.671875 "/>
</g>
<g id="glyph-1-0">
<path d="M 0.515625 1.859375 L 0.515625 -7.390625 L 5.765625 -7.390625 L 5.765625 1.859375 Z M 1.109375 1.265625 L 5.1875 1.265625 L 5.1875 -6.796875 L 1.109375 -6.796875 Z M 1.109375 1.265625 "/>
</g>
<g id="glyph-1-1">
<path d="M 4.25 -4.125 C 4.75 -4.019531 5.132812 -3.796875 5.40625 -3.453125 C 5.6875 -3.117188 5.828125 -2.707031 5.828125 -2.21875 C 5.828125 -1.46875 5.566406 -0.882812 5.046875 -0.46875 C 4.535156 -0.0507812 3.800781 0.15625 2.84375 0.15625 C 2.519531 0.15625 2.1875 0.117188 1.84375 0.046875 C 1.507812 -0.015625 1.160156 -0.109375 0.796875 -0.234375 L 0.796875 -1.234375 C 1.085938 -1.066406 1.398438 -0.9375 1.734375 -0.84375 C 2.078125 -0.757812 2.4375 -0.71875 2.8125 -0.71875 C 3.457031 -0.71875 3.945312 -0.84375 4.28125 -1.09375 C 4.625 -1.351562 4.796875 -1.726562 4.796875 -2.21875 C 4.796875 -2.664062 4.640625 -3.015625 4.328125 -3.265625 C 4.015625 -3.523438 3.578125 -3.65625 3.015625 -3.65625 L 2.125 -3.65625 L 2.125 -4.515625 L 3.046875 -4.515625 C 3.554688 -4.515625 3.945312 -4.613281 4.21875 -4.8125 C 4.488281 -5.019531 4.625 -5.3125 4.625 -5.6875 C 4.625 -6.082031 4.484375 -6.382812 4.203125 -6.59375 C 3.921875 -6.800781 3.523438 -6.90625 3.015625 -6.90625 C 2.722656 -6.90625 2.414062 -6.875 2.09375 -6.8125 C 1.769531 -6.757812 1.414062 -6.664062 1.03125 -6.53125 L 1.03125 -7.453125 C 1.425781 -7.566406 1.789062 -7.648438 2.125 -7.703125 C 2.46875 -7.753906 2.796875 -7.78125 3.109375 -7.78125 C 3.890625 -7.78125 4.507812 -7.601562 4.96875 -7.25 C 5.425781 -6.894531 5.65625 -6.410156 5.65625 -5.796875 C 5.65625 -5.378906 5.53125 -5.023438 5.28125 -4.734375 C 5.039062 -4.441406 4.695312 -4.238281 4.25 -4.125 Z M 4.25 -4.125 "/>
</g>
</g>
</defs>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 6.932212 5.042038 L 6.932212 4.254563 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 6.940556 4.268968 L 6.024037 3.739878 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 6.032382 3.754282 L 6.032382 2.705541 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 6.032382 2.705541 L 6.032382 1.927701 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 6.032382 2.705541 L 4.993276 2.705541 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 4.993276 2.705541 L 4.468855 3.613715 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 4.483359 3.60537 L 3.434617 3.60537 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 3.434617 3.60537 L 3.399749 2.700673 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 3.397563 2.709713 L 3.679393 2.221452 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 3.277261 2.584643 L 3.511011 2.179729 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 3.672737 2.22781 L 4.473723 1.805611 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 4.473723 1.805611 L 3.434617 1.805611 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 3.434617 1.805611 L 2.914965 2.705541 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 2.914965 2.705541 L 2.804895 3.164992 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 2.799928 3.1488 L 3.296037 3.60537 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 3.296037 3.60537 L 3.033678 3.846868 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 2.873639 4.332645 L 2.914965 4.5053 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 2.914965 4.5053 L 2.331635 3.62951 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 2.339086 3.635669 L 1.057787 3.100222 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.057986 3.100222 L 1.904569 2.485103 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.898608 2.489474 L 1.790029 1.456031 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.722775 2.411194 L 1.634262 1.56918 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.796784 1.459011 L 0.831886 1.029461 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 0.840727 1.033335 L -0.00774338 1.649845 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 0.860794 1.224765 L 0.167991 1.728126 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M -0.000988195 1.634546 L 0.109678 2.687163 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 0.841721 1.042971 L 0.760658 0.271391 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.783174 1.459011 L 2.459388 1.158008 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 2.581676 4.265193 L 1.588466 5.189262 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 4.473723 1.805611 L 4.831052 1.186618 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 5.238251 0.905682 L 5.804792 0.905682 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 6.032382 2.705541 L 6.826513 2.705541 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 4.473723 1.805611 L 4.993276 2.705541 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 2.914965 2.705541 L 3.434617 3.60537 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 2.914965 4.5053 L 3.434617 3.60537 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 2.960463 1.279005 L 3.434617 1.805611 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.891357 2.487885 L 2.914965 2.705541 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 0.0998428 2.673652 L 1.058184 3.100321 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 0.25551 2.560602 L 1.038018 2.908891 " transform="matrix(39.321671, 0, 0, 39.321671, 2.691201, 43.418311)"/>
<g fill="rgb(0%, 0%, 0%)" fill-opacity="1">
<use xlink:href="#glyph-0-1" x="269.773438" y="257.679688"/>
</g>
<g fill="rgb(0%, 0%, 0%)" fill-opacity="1">
<use xlink:href="#glyph-0-2" x="279.667969" y="257.472656"/>
</g>
<g fill="rgb(0%, 0%, 0%)" fill-opacity="1">
<use xlink:href="#glyph-1-1" x="290.464844" y="258.375"/>
</g>
<g fill="rgb(0%, 0%, 0%)" fill-opacity="1">
<use xlink:href="#glyph-0-1" x="234.386719" y="114.671875"/>
</g>
<g fill="rgb(0%, 0%, 0%)" fill-opacity="1">
<use xlink:href="#glyph-0-2" x="244.285156" y="114.464844"/>
</g>
<g fill="rgb(0%, 0%, 0%)" fill-opacity="1">
<use xlink:href="#glyph-1-1" x="255.082031" y="115.367188"/>
</g>
<g fill="rgb(19%, 31%, 97.000003%)" fill-opacity="1">
<use xlink:href="#glyph-0-3" x="107.191406" y="208.617188"/>
</g>
<g fill="rgb(100%, 5.1%, 5.1%)" fill-opacity="1">
<use xlink:href="#glyph-0-4" x="25.289062" y="49.144531"/>
</g>
<g fill="rgb(100%, 5.1%, 5.1%)" fill-opacity="1">
<use xlink:href="#glyph-0-2" x="36.550781" y="48.9375"/>
</g>
<g fill="rgb(100%, 5.1%, 5.1%)" fill-opacity="1">
<use xlink:href="#glyph-0-4" x="104.214844" y="89.777344"/>
</g>
<g fill="rgb(0%, 0%, 0%)" fill-opacity="1">
<use xlink:href="#glyph-0-1" x="50.515625" y="261.6875"/>
</g>
<g fill="rgb(0%, 0%, 0%)" fill-opacity="1">
<use xlink:href="#glyph-0-2" x="33.464844" y="261.480469"/>
</g>
<g fill="rgb(0%, 0%, 0%)" fill-opacity="1">
<use xlink:href="#glyph-1-1" x="44.257813" y="262.382812"/>
</g>
<g fill="rgb(100%, 5.1%, 5.1%)" fill-opacity="1">
<use xlink:href="#glyph-0-4" x="192.84375" y="84.757812"/>
</g>
<g fill="rgb(0%, 0%, 0%)" fill-opacity="1">
<use xlink:href="#glyph-0-1" x="234.386719" y="84.757812"/>
</g>
<g fill="rgb(0%, 0%, 0%)" fill-opacity="1">
<use xlink:href="#glyph-0-2" x="244.285156" y="84.550781"/>
</g>
<g fill="rgb(0%, 0%, 0%)" fill-opacity="1">
<use xlink:href="#glyph-1-1" x="255.082031" y="85.453125"/>
</g>
<g fill="rgb(100%, 5.1%, 5.1%)" fill-opacity="1">
<use xlink:href="#glyph-0-4" x="274.5625" y="155.53125"/>
</g>
<g fill="rgb(100%, 5.1%, 5.1%)" fill-opacity="1">
<use xlink:href="#glyph-0-2" x="285.828125" y="155.324219"/>
</g>
</svg>
)
