3-Phenyl-4,8-dihydro-toxoflavin | 57562-70-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-Phenyl-4,8-dihydro-toxoflavin
• 英文别名: 1,6-dimethyl-3-phenyl-4,8-dihydro-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione；1,6-dimethyl-3-phenyl-4,8-dihydropyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione；1,6-dimethyl-3-phenyl-2,8-dihydropyrimido[5,4-e][1,2,4]triazine-5,7-dione
• CAS: 57562-70-6
• 化学式: C₁₃H₁₃N₅O₂
• 分子量: 271.279
• InChiKey: CEADCIIWZQASEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  77
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• COMPOUNDS AND METHODS FOR TREATING TUBERCULOSIS INFECTION
  申请人：Wong Chi-Huey

  公开号：US20130158037A1

  公开（公告）日：2013-06-20

  The present invention provides compounds which are potent inhibitors against Lpd activity, PDH activity, and/or the growth of tubercle bacillus , and thus are useful in the treatment of tuberculosis infection and associated conditions. The present invention is further directed to in vitro- and in vzivo-based methods of inhibiting Lpd and/or PDH activity. In certain embodiments, these methods are useful in inhibiting Lpd and/or PDH activity key to a pathogen's survival.
• US9073941B2
  申请人：——

  公开号：US9073941B2

  公开（公告）日：2015-07-07
• [EN] INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE<br/>[FR] INHIBITEURS DE CYSTATHIONINE BÊTA-SYNTHASE POUR RÉDUIRE LA SURPRODUCTION NEUROTOXIQUE DE SULFURE D'HYDROGÈNE ENDOGÈNE
  申请人：FOND JEROME LEJEUNE

  公开号：WO2010072807A2

  公开（公告）日：2010-07-01

  The invention is directed to inhibitors of cystathionine beta synthase which, among other biochemical effects, allow reduction of the neurotoxic overproduction of endogenous hydrogen sulphide. These compounds and pharmaceutical compositions containing them are useful for the prevention and treatment of neurotoxic and cognitive disorders such as cognitive disorders in Down syndrome. The invention also relates to methods for preventing or treating neurotoxic and cognitive disorders including cognitive disorders in Down Syndrome.