spinosan A | 877932-10-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: spinosan A
• 英文别名: 6-(4-hydroxy-2-methoxyphenyl)furo[2,3-f][1,3]benzodioxole-7-carbaldehyde
• CAS: 877932-10-0
• 化学式: C₁₇H₁₂O₆
• 分子量: 312.279
• InChiKey: DIWHINIZDYGBCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  78.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  spinosan A 、 乙酸酐 在 三乙胺 作用下， 反应 1.5h， 以9 mg的产率得到Spinosan A Acetate
  参考文献：
  名称：

  Metabolites of the “Smoke Tree”, Dalea spinosa, Potentiate Antibiotic Activity against Multidrug-Resistant Staphylococcus aureus

  摘要：

  Two new 2-arylbenzofuran aldehydes (1 and 2) and three known phenolic compounds (3-5) were isolated from organic extracts of Dalea spinosa. These compounds were evaluated for their intrinsic antimicrobial activity and. their ability to perform as multidrug-resistance inhibitors by potentiating the activity of known antimicrobials against a variety of pathogenic microorganisms. Compound 1 and its acetate derivative 6 exhibited no direct antimicrobial activity but enhanced the effect of the weak plant antimicrobial berberine when tested against Staphylococcus aureus. Additional potentiation assays with S. aureus overexpression and knockout isogenic efflux mutants for the NorA pump were done in order to assess whether the potentiating effects were associated with inhibition of this known pump mechanism.

  DOI：

  10.1021/np058057s

文献信息

• Metabolites of the “Smoke Tree”, <i>Dalea spinosa</i>, Potentiate Antibiotic Activity against Multidrug-Resistant <i>Staphylococcus aureus</i>
  作者：Gil Belofsky、Roberto Carreno、Kim Lewis、Anthony Ball、Gabriele Casadei、George P. Tegos

  DOI：10.1021/np058057s

  日期：2006.2.1

  Two new 2-arylbenzofuran aldehydes (1 and 2) and three known phenolic compounds (3-5) were isolated from organic extracts of Dalea spinosa. These compounds were evaluated for their intrinsic antimicrobial activity and. their ability to perform as multidrug-resistance inhibitors by potentiating the activity of known antimicrobials against a variety of pathogenic microorganisms. Compound 1 and its acetate derivative 6 exhibited no direct antimicrobial activity but enhanced the effect of the weak plant antimicrobial berberine when tested against Staphylococcus aureus. Additional potentiation assays with S. aureus overexpression and knockout isogenic efflux mutants for the NorA pump were done in order to assess whether the potentiating effects were associated with inhibition of this known pump mechanism.

表征谱图