Colladonin | 77448-55-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: Colladonin
• 英文别名: Gummosin；Farnesiferol A；7-[(6-hydroxy-5,5,8a-trimethyl-2-methylidene-decahydronaphthalen-1-yl)methoxy]-2H-chromen-2-one；7-[(6-hydroxy-5,5,8a-trimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl)methoxy]chromen-2-one
• CAS: 77448-55-6
• 化学式: C₂₄H₃₀O₄
• 分子量: 382.5
• InChiKey: FCWYNTDTQPCVPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Small molecules against cancer
  申请人：Biokine Therapeutics Ltd.

  公开号：US10646465B2

  公开（公告）日：2020-05-12

  Compounds capable of, or usable in, killing cancer cells, and/or modulating a biological activity of a chemokine, and/or inhibiting a kinase, and/or treating diseases and disorders associated with a biological activity of a chemokine and/or cell migration, and/or treating disease and disorders such as cancer and inflammatory diseases and disorders, are provided herein. The compounds are listed in Tables 2, 4 and 5, and/or are represented by Formulae I, IV, V and VI, as defined in the specification. Methods utilizing these compounds are also provided.

  本文提供的化合物能够或可用于杀死癌细胞，和/或调节趋化因子的生物活性，和/或抑制激酶，和/或治疗与趋化因子的生物活性和/或细胞迁移相关的疾病和紊乱，和/或治疗疾病和紊乱，如癌症和炎症性疾病和紊乱。这些化合物列于表 2、表 4 和表 5 中，和/或由式 I、式 IV、式 V 和式 VI 表示，如说明书中所定义。还提供了利用这些化合物的方法。
• SMALL MOLECULES AGAINST CANCER
  申请人：Biokine Therapeutics Ltd.

  公开号：US20190240188A1

  公开（公告）日：2019-08-08

  Compounds capable of, or usable in, killing cancer cells, and/or modulating a biological activity of a chemokine, and/or inhibiting a kinase, and/or treating diseases and disorders associated with a biological activity of a chemokine and/or cell migration, and/or treating disease and disorders such as cancer and inflammatory diseases and disorders, are provided herein. The compounds are listed in Tables 2, 4 and 5, and/or are represented by Formulae I, IV, V and VI, as defined in the specification. Methods utilizing these compounds are also provided.
• [DE] KOSMETISCHE ODER DERMATOLOGISCHE ZUBEREITUNGEN MIT EINEM GEHALT AN DECALINDERIVATEN UND VERWENDUNG VON DECALINDERIVATEN ZUR BRÄUNUNG DER HAUT<br/>[EN] COSMETIC OR DERMATOLOGICAL PREPARATIONS HAVING A CONTENT OF DECALINE DERIVATIVES AND USE OF DECALINE DERIVATIVES FOR TANNING THE SKIN<br/>[FR] PRÉPARATIONS COSMÉTIQUES OU DERMATOLOGIQUES CONTENANT DES DÉRIVÉS DE DÉCALINE ET UTILISATION DE DÉRIVÉS DE DÉCALINE POUR LE BRONZAGE DE LA PEAU
  申请人：BEIERSDORF AG

  公开号：WO2015135606A1

  公开（公告）日：2015-09-17

  Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an einem oder mehreren Decalinderivaten und Verwendung von einem oder mehreren Decalinderivaten zur Herstellung kosmetischer Zubereitungen zur Bräunung der Haut.
• [EN] SMALL MOLECULES AGAINST CANCER<br/>[FR] PETITES MOLÉCULES CONTRE LE CANCER
  申请人：BIOKINE THERAPEUTICS LTD

  公开号：WO2017103931A1

  公开（公告）日：2017-06-22

  Compounds capable of, or usable in, killing cancer cells, and/or modulating a biological activity of a chemokine, and/or inhibiting a kinase, and/or treating diseases and disorders associated with a biological activity of a chemokine and/or cell migration, and/or treating disease and disorders such as cancer and inflammatory diseases and disorders, are provided herein. The compounds are listed in Tables 2, 4 and 5, and/or are represented by Formulae I, IV, V and VI, as defined in the specification. Methods utilizing these compounds are also provided.