5,5'-二[(1E)-1-丙烯-1-基]-2,2'-联苯二醇 | 87979-85-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5,5'-二[(1E)-1-丙烯-1-基]-2,2'-联苯二醇
• 中文别名: 氯化二甲基[2-[(2-甲基-1-羰基烯丙基)氧代]乙基][3-(三乙氧基甲硅烷基)丙基]铵
• 英文名称: trans-Isomagnolol
• 英文别名: isomagnolol；6.6'-Dihydroxy-3.3'-dipropenyl-biphenyl；5,5'-Dipropenyl-biphenyl-2,2'-diol；(1,1'-Biphenyl)-2,2'-diol, 5,5'-di-(1E)-1-propenyl-；2-[2-hydroxy-5-[(E)-prop-1-enyl]phenyl]-4-[(E)-prop-1-enyl]phenol
• CAS: 87979-85-9
• 化学式: C₁₈H₁₈O₂
• 分子量: 266.34
• InChiKey: VLRNWUFGTCSJDO-GGWOSOGESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2907299090

反应信息

• 作为反应物：
  描述：

  5,5'-二[(1E)-1-丙烯-1-基]-2,2'-联苯二醇 在 乙醇 、 钯 作用下， 生成 二丙基联苯二醇
  参考文献：
  名称：

  Older Women's Community Mobility: A Qualitative Exploration

  摘要：

  摘要居住在社区的老年妇女所经历的许多限制都与她们在社区内的流动性有关。这项定性研究从马尼托巴省温尼伯市居住在社区的老年妇女的角度探讨了社区流动性问题。通过现有数据库确定了 23 名老年妇女（平均年龄为 75.9 岁），并对她们进行了半结构式访谈。除了进行日常生活工具性活动和参加社交及娱乐活动的旅行外，参与研究的妇女还描述了为履行社会义务（如参加葬礼、探望生病的朋友）而进行的旅行，并强调了这些旅行的重要性。妇女们在城市中的出行受到了她们对风险的感知以及在白天、傍晚和恶劣天气下为尽量减少或避免风险而采取的策略的影响。自主的社区流动为妇女提供了一种独立感和控制感。研究结果对医疗服务提供者和社区计划制定者在社区中维护老年妇女的工作具有潜在的意义。

  DOI：

  10.1017/s0714980800000659
• 作为产物：
  描述：

  厚朴酚 在 氢氧化钾 、 异戊醇 作用下， 生成 5,5'-二[(1E)-1-丙烯-1-基]-2,2'-联苯二醇
  参考文献：
  名称：

  Older Women's Community Mobility: A Qualitative Exploration

  摘要：

  摘要居住在社区的老年妇女所经历的许多限制都与她们在社区内的流动性有关。这项定性研究从马尼托巴省温尼伯市居住在社区的老年妇女的角度探讨了社区流动性问题。通过现有数据库确定了 23 名老年妇女（平均年龄为 75.9 岁），并对她们进行了半结构式访谈。除了进行日常生活工具性活动和参加社交及娱乐活动的旅行外，参与研究的妇女还描述了为履行社会义务（如参加葬礼、探望生病的朋友）而进行的旅行，并强调了这些旅行的重要性。妇女们在城市中的出行受到了她们对风险的感知以及在白天、傍晚和恶劣天气下为尽量减少或避免风险而采取的策略的影响。自主的社区流动为妇女提供了一种独立感和控制感。研究结果对医疗服务提供者和社区计划制定者在社区中维护老年妇女的工作具有潜在的意义。

  DOI：

  10.1017/s0714980800000659

文献信息

• Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB₂ Receptors and Blockade of the Related GPR55
  作者：Viktor Rempel、Alexander Fuchs、Sonja Hinz、Tadeusz Karcz、Matthias Lehr、Uwe Koetter、Christa E. Müller

  DOI：10.1021/ml300235q

  日期：2013.1.10

  The bark of Magnolia officinalis is used in Asian traditional medicine for the treatment of anxiety, sleeping disorders, and allergic diseases. We found that the extract and its main bioactive constituents, magnolol and honokiol, can activate cannabinoid (CB) receptors. In cAMP accumulation studies, magnolol behaved as a partial agonist (EC50 = 3.28 mu M) with selectivity for the CB2 subtype, while honokiol was less potent showing full agonistic activity at CB1 and antagonistic properties at CB2. We subsequently synthesized the major metabolites of magnolol and found that tetrahydromagnolol (7) was 19-fold more potent than magnolol (EC50 CB2 = 0.170 mu M) exhibiting high selectivity versus CB1. Additionally, 7 behaved as an antagonist at GPR55, a CB-related orphan receptor (K-B = 13.3 mu M, beta-arrestin translocation assay). Magnolol and its metabolites may contribute to the biological activities of Magnolia extract via the observed mechanisms of action. Furthermore, the biphenylic compound magnolol provides a simple novel lead structure for the development of agonists for CB receptors and antagonists for the related GPR55.
• MONOMERS, POLYMERS AND METHODS OF MAKING THE SAME
  申请人：Alliance for Sustainable Energy, LLC

  公开号：US20200095351A1

  公开（公告）日：2020-03-26

  The present disclosure relates to compositions that include at least one of where each of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 includes at least one of a carbon atom, a hydrogen atom, an oxygen atom, a nitrogen atom, and/or a halogen atom, each of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 may be different or the same, and 1≥z≥50,000.
• Older Women's Community Mobility: A Qualitative Exploration
  作者：Marcia Finlayson、Joseph Kaufert

  DOI：10.1017/s0714980800000659

  日期：——

  Many of the limitations experienced by community-dwelling older women are related to mobility within their communities. This qualitative study explored community mobility from the perspective of older, community-dwelling women in Winnipeg, Manitoba. Semi-structured interviews were completed with 23 older women (mean age 75.9 years) identified through an existing database. In addition to travels to conduct instrumental activities of daily living and participate in social and recreational activities, the women in the study described trips to fulfil social obligations (e.g., attending funerals, visiting sick friends) and emphasized the importance of these trips. The women's travels through the city were influenced by their perception of risk and the strategies they employed to minimize or avoid risk during the day, in the evening, and during bad weather. Autonomous community mobility provided the women with a sense of independence and control. The findings have potential implications for health care providers and community programmers who work to maintain older women in the community.

  摘要居住在社区的老年妇女所经历的许多限制都与她们在社区内的流动性有关。这项定性研究从马尼托巴省温尼伯市居住在社区的老年妇女的角度探讨了社区流动性问题。通过现有数据库确定了 23 名老年妇女（平均年龄为 75.9 岁），并对她们进行了半结构式访谈。除了进行日常生活工具性活动和参加社交及娱乐活动的旅行外，参与研究的妇女还描述了为履行社会义务（如参加葬礼、探望生病的朋友）而进行的旅行，并强调了这些旅行的重要性。妇女们在城市中的出行受到了她们对风险的感知以及在白天、傍晚和恶劣天气下为尽量减少或避免风险而采取的策略的影响。自主的社区流动为妇女提供了一种独立感和控制感。研究结果对医疗服务提供者和社区计划制定者在社区中维护老年妇女的工作具有潜在的意义。
• Cytotoxic neolignans: an SAR study
  作者：Zwe-Ling Kong、Shin-Cheng Tzeng、Yeuk-Chuen Liu

  DOI：10.1016/j.bmcl.2004.10.011

  日期：2005.1

  The neolignans, magnolol 1 and honokiol 2 have been reported to inhibit the growth of several tumor cell lines in vitro and in vivo. The chemical structure of magnolol and honokiol consists of biphenyl skeleton with phenolic and allylic functionalities. Analogs of 1 and 2 containing different substitution have been studies for their effect on the growth of Hep-G2 and their structure-activity relationships were reported in this work. (C) 2004 Elsevier Ltd. All rights reserved.