farinomalein B | 1175524-10-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: farinomalein B
• 英文别名: farinomalein methyl ester；Methyl 3-(2,5-dioxo-3-propan-2-ylpyrrol-1-yl)propanoate
• CAS: 1175524-10-3
• 化学式: C₁₁H₁₅NO₄
• 分子量: 225.244
• InChiKey: GAWITTZBYGKEMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-isopropylfuran-2,5-dione 、 3-氨基丙酸甲酯盐酸盐 在 溶剂黄146 、 lithium hydroxide 作用下， 生成 farinomalein B
  参考文献：
  名称：

  Synthesis of farinomalein

  摘要：

  Farinomalein, a recently isolated maleimide from Paecilomyces farinosus, was synthesized in two steps from a readily available gamma-hydroxybutenolide. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.01.083

文献信息

• Farinomalein, a Maleimide-Bearing Compound from the Entomopathogenic Fungus <i>Paecilomyces farinosus</i>
  作者：Sastia P. Putri、Hiroshi Kinoshita、Fumio Ihara、Yasuhiro Igarashi、Takuya Nihira

  DOI：10.1021/np9002806

  日期：2009.8.28

  A new maleimide-bearing compound, farinomalein (1), was isolated from the entomopathogenic fungus Paecilomyces farinosus HF599. The structure was determined on the basis of spectroscopic analyses and chemical conversion. Compound 1 showed potent activity (5 mu g/disk) against the plant pathogenic Phytophthora sojae P6497.
• Synthesis of farinomalein
  作者：William H. Miles、Ming Yan

  DOI：10.1016/j.tetlet.2010.01.083

  日期：2010.3

  Farinomalein, a recently isolated maleimide from Paecilomyces farinosus, was synthesized in two steps from a readily available gamma-hydroxybutenolide. (C) 2010 Elsevier Ltd. All rights reserved.