2-dimethylphenylsilyl-4-methylbenzaldehyde | 1196117-39-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-dimethylphenylsilyl-4-methylbenzaldehyde
• 英文别名: 2-[Dimethyl(phenyl)silyl]-4-methylbenzaldehyde；2-[dimethyl(phenyl)silyl]-4-methylbenzaldehyde
• CAS: 1196117-39-1
• 化学式: C₁₆H₁₈OSi
• 分子量: 254.404
• InChiKey: QXPZYDOIJBQCHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.63
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  potassium 4-methyl-1-phenyl-2,6,7-trioxa-1-borate-bicyclo[2.2.2]octane 、 2-dimethylphenylsilyl-4-methylbenzaldehyde 在 bis(1,5-cyclooctadiene)nickel (0) 、 (-)-1,2-双((2R,5R)-2,5-二乙磷酰亚基)苯 作用下， 以 乙醇 、 水 为溶剂， 反应 20.0h， 以70%的产率得到(R)-(2-dimethylphenylsilyl-4-methylphenyl)phenylmethanol
  参考文献：
  名称：

  Et-duphos-nickel-catalyzed asymmetric arylation of benzaldehyde derivatives bearing an ortho-Me2PhSi group with potassium aryltriolborates

  摘要：

  The Ni-catalyzed asymmetric arylation of benzaldehydes bearing an ortho-masked H group with potassium aryltriolborates has been developed. The keys to success were (i) steric tuning of benzaldehyde derivatives with an ortho-Me2PhSi group, and (ii) the use of potassium aryltriolborates as aryl sources. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.019
• 作为产物：
  描述：

  2-溴-4-甲基苯甲醛 、 苯基二甲基氯硅烷 在 对甲苯磺酸 、 正丁基锂 作用下， 以 乙醇 、 乙醚 、 正己烷 为溶剂， 反应 22.0h， 生成 2-dimethylphenylsilyl-4-methylbenzaldehyde
  参考文献：
  名称：

  Et-duphos-nickel-catalyzed asymmetric arylation of benzaldehyde derivatives bearing an ortho-Me2PhSi group with potassium aryltriolborates

  摘要：

  The Ni-catalyzed asymmetric arylation of benzaldehydes bearing an ortho-masked H group with potassium aryltriolborates has been developed. The keys to success were (i) steric tuning of benzaldehyde derivatives with an ortho-Me2PhSi group, and (ii) the use of potassium aryltriolborates as aryl sources. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.019

文献信息

• Et-duphos-nickel-catalyzed asymmetric arylation of benzaldehyde derivatives bearing an ortho-Me2PhSi group with potassium aryltriolborates
  作者：Fumie Sakurai、Kazuhiro Kondo、Toyohiko Aoyama

  DOI：10.1016/j.tetlet.2009.08.019

  日期：2009.11

  The Ni-catalyzed asymmetric arylation of benzaldehydes bearing an ortho-masked H group with potassium aryltriolborates has been developed. The keys to success were (i) steric tuning of benzaldehyde derivatives with an ortho-Me2PhSi group, and (ii) the use of potassium aryltriolborates as aryl sources. (C) 2009 Elsevier Ltd. All rights reserved.