4-butyl-7,8-dihydroxy-2H-chromen-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-butyl-7,8-dihydroxy-2H-chromen-2-one
• 英文别名: 4-butyl-7,8-dihydroxychromen-2-one
• 化学式: C₁₃H₁₄O₄
• mdl: MFCD05997315
• 分子量: 234.25
• InChiKey: GDGBIWNBPUQGGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.307
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Compositions and Methods for Reactivating Latent Immunodeficiency Virus
  申请人：The J. David Gladstone Institutes

  公开号：US20150133434A1

  公开（公告）日：2015-05-14

  The present disclosure provides compositions and methods for reactivating latent immunodeficiency vims. The methods generally involve contacting an HIV-infected cell in which HIV is latent with an agent that binds a bromodomain (BRD) in the cell. Latently infected cells contain replication-competent integrated HIV-1 genomes that are blocked at the transcriptional level, resulting in the absence of viral protein expression. The present disclosure provides methods for reducing the reservoir of latent immunodeficiency virus in an individual.