Norcodein | 858224-53-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: Norcodein
• 英文别名: 4,5α-epoxy-3-methoxy-morphin-7-en-6α-ol；N-Norcodeine；9-methoxy-1,2,3,4,4a,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
• CAS: 858224-53-0
• 化学式: C₁₇H₁₉NO₃
• 分子量: 285.343
• InChiKey: HKOIXWVRNLGFOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  50.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] TARGETED DRUG DELIVERY THROUGH AFFINITY BASED LINKERS<br/>[FR] ADMINISTRATION CIBLÉE D'UN MÉDICAMENT FAISANT APPEL À DES COUPLEURS FONDÉS SUR L'AFFINITÉ
  申请人：INVICTUS ONCOLOGY PVT LTD

  公开号：WO2015148126A1

  公开（公告）日：2015-10-01

  The current invention discloses targeted drug delivery conjugates comprising a targeting moiety linked to a drug via a molecule having an affinity for the targeting moiety. Typically, the conjugate comprises a targeting ligand and a molecule of interest, e.g., a therapeutic agent. The targeting ligand and the molecule of interest are linked to each other via an affinity ligand. The affinity ligand is further covalently or non-covalently linked to a drug or therapeutic agent. The drug can be modified to make it more soluble and so that it cleaves from the linking molecule at the target site.

  当前的发明揭示了包括通过具有与靶向基团亲和力的分子连接到药物的靶向药物传递共轭物。通常，该共轭物包括一个靶向配体和一个感兴趣的分子，例如，一个治疗剂。靶向配体和感兴趣的分子通过一个亲和配体相互连接。该亲和配体进一步以共价或非共价方式连接到药物或治疗剂。药物可以被修改以使其更溶解，并使其在靶点处从连接分子中解离。
• Compositions and Methods For Making Alkaloid Morphinans
  申请人：EPIMERON INC.

  公开号：US20170267686A1

  公开（公告）日：2017-09-21

  Methods that may be used for the manufacture of a class of chemical compounds known as morphinans, including neopine, are provided. Compositions useful for the synthesis of morphinans, including neopine, are also provided.

  提供了用于制造一类被称为吗啡酮的化合物的方法，包括新吗啡酮。还提供了用于合成吗啡酮，包括新吗啡酮的组合物。
• Methods of synthesis of morphinans
  申请人：Lawson John A.

  公开号：US20090318699A1

  公开（公告）日：2009-12-24

  The disclosure describes morphinan compounds and methods for their synthesis. Preferred methods according to the disclosure allow for large-scale preparation of diastereomerically enriched morphinans. Preferred methods according to the disclosure may also allow for the preparation of diastereomerically enriched morphinans using less time, and/or using fewer reaction steps, and/or providing better yield than previously used methods for preparing morphinans. The methods disclosed herein find utility in synthetic organic chemistry as well as medicinal chemistry.

  该披露描述了吗啡醇类化合物及其合成方法。根据该披露的首选方法允许大规模制备对映体富集的吗啡醇类化合物。根据该披露的首选方法还可以在较短的时间内制备对映体富集的吗啡醇类化合物，或者使用更少的反应步骤，或者提供比以前用于制备吗啡醇类化合物的方法更好的产量。本文披露的方法在合成有机化学以及药物化学中具有实用性。
• METHODS AND COMPOSITIONS FOR PREVENTING OPIOID ABUSE
  申请人：Waterville Valley Technologies, Inc.

  公开号：US20160326182A1

  公开（公告）日：2016-11-10

  Abuse-resistant opioid compounds, drug delivery systems, pharmaceutical compositions comprising an opioid covalently bound to a chemical moiety are provided. Methods of delivering an active ingredient to a subject and methods of preventing opioid abuse are also provided.

  提供了耐滥用的阿片类化合物、药物输送系统、含有阿片类药物与化学基团共价结合的制药组合物。还提供了将活性成分输送给受试者的方法以及预防阿片类药物滥用的方法。
• Preparation of 10-Keto Morphinans by Benzylic Oxidation
  申请人：Sun Hang

  公开号：US20110071296A1

  公开（公告）日：2011-03-24

  The present invention provides processes for the preparation of 10-keto and/or 10-hydroxy morphinans. In particular, the invention provides to processes for preparing a 10-keto morphinan by chromium-catalyzed benzylic oxidation of a morphinan with a periodic acid.

  本发明提供了制备10-酮基和/或10-羟基吗啡酮类化合物的方法。具体而言，该发明提供了一种通过铬催化苯基氧化吗啡酮类化合物以制备10-酮基吗啡酮的方法。

表征谱图