aspergillic acid | 22810-67-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: aspergillic acid
• 英文别名: DL-Aspergillsaeure；6-sec-butyl-1-hydroxy-3-isobutyl-1H-pyrazin-2-one；6-butan-2-yl-1-hydroxy-3-(2-methylpropyl)pyrazin-2-one
• CAS: 22810-67-9
• 化学式: C₁₂H₂₀N₂O₂
• 分子量: 224.303
• InChiKey: IUZCDJYHMMWBBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] ANTIBACTERIAL SIDEROMYCINS<br/>[FR] SIDÉROMYCINES ANTIBACTÉRIENNES
  申请人：MILLER MARVIN J

  公开号：WO2016027262A1

  公开（公告）日：2016-02-25

  A compound, comprising: an Fe(III)-binding and/or Fe(III)-bound siderophore; one or more optional linker covalently bound to the siderophore; and daptomycin covalently bound to the linker, or, if no linker is present, then to the siderophore; or pharmaceutically acceptable salt or solvate thereof.

  一种化合物，包括：与Fe(III)结合和/或Fe(III)结合的铁载体；一个或多个可选的与铁载体共价结合的连接剂；以及共价结合到连接剂的达托霉素，或者如果没有连接剂存在，则共价结合到铁载体；或其药用可接受的盐或溶剂。
• [EN] CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS<br/>[FR] PEROXYDES CYCLIQUES UTILISÉS EN TANT QUE PROMÉDICAMENTS POUR L'ADMINISTRATION SÉLECTIVE D'AGENTS
  申请人：UNIV CALIFORNIA

  公开号：WO2015123595A1

  公开（公告）日：2015-08-20

  Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa- 8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a phannaceutically acceptable carrier.

  本文披露了前药组合物及其用于治疗和检测疾病的方法。具体地，本文披露了一种具有螺合1,2,4-三噁烷和哌啶环的化合物的公式(I)，即1,2,4-三氧杂-8-氮杂螺[4.5]癸烷。还披露了含有该化合物和药用载体的药物组合物。
• SURFACE-MODIFIED ZIRCONIA NANOPARTICLES
  申请人：Shultz Nathan E.

  公开号：US20110288215A1

  公开（公告）日：2011-11-24

  Surface-modified zirconia nanoparticles and methods for making and using the same are provided. The surface-modifiers include non-metallic organic derivatives, comprising at least one hydroxamate functionality, wherein at least some of the non-metallic organic derivatives are attached to at least some of the zirconia nanoparticles.

  提供了表面改性的氧化锆纳米颗粒及其制备和使用方法。表面改性剂包括非金属有机衍生物，包括至少一个羟酰胺功能基团，其中至少一些非金属有机衍生物附着在至少一些氧化锆纳米颗粒上。
• RADIATION SENSITIVE LIPOSOMES
  申请人：Bondurant Bruce

  公开号：US20090304589A1

  公开（公告）日：2009-12-10

  The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposome composition comprising a stable liposome-forming lipid and a polymerizable colipid, and a chain transfer agent. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.

  本发明涉及一种辐射敏感的脂质体，以及将该脂质体用作治疗和诊断药物的载体。特别地，本发明涵盖了一种脂质体组合物，包括稳定的脂质体形成脂质和可聚合的共脂质以及链转移剂。本发明还涵盖了利用脂质体封装或关联的药物诊断和治疗对脂质体敏感的疾病和病症的方法。
• Superoxide dismutase mimic
  申请人：DUKE UNIVERSITY

  公开号：EP0284645A2

  公开（公告）日：1988-10-05

  The invention relates to a water-soluble complex formed between a chelating agent and manganese and pharmaceutical compositions thereof. The complex is a low molecular weight mimic of superoxide dismutase. The invention further relates to a method of using the complex comprising treating plant and animal cells with an amount of the complex sufficient to reduce or prevent superoxide radical-­induced toxicity.

  本发明涉及一种螯合剂与锰之间形成的水溶性复合物及其药物组合物。该复合物是超氧化物歧化酶的低分子量模拟物。本发明还涉及一种使用该复合物的方法，包括用一定量的该复合物处理植物和动物细胞，以减少或防止超氧自由基引起的毒性。