2',4'-Dihydroxy-3'-(2-hydroxybenzyl)-6'-methoxychalcone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 2',4'-Dihydroxy-3'-(2-hydroxybenzyl)-6'-methoxychalcone
• 英文别名: 1-[2,4-dihydroxy-3-[(2-hydroxyphenyl)methyl]-6-methoxyphenyl]-3-phenylprop-2-en-1-one
• 化学式: C₂₃H₂₀O₅
• 分子量: 376.4
• InChiKey: IVKGLRZLTNXWKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] MACC1 INHIBITORS AND USE THEREOF IN THE TREATMENT OF CANCER<br/>[FR] INHIBITEURS DE MACC1 ET LEUR UTILISATION DANS LE TRAITEMENT DU CANCER
  申请人：CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN

  公开号：WO2016020427A1

  公开（公告）日：2016-02-11

  The invention relates to MACC1 inhibitors for use as a medicament in the treatment of cancer. The invention provides compounds of general formula I that show beneficial effects in restricting cell proliferation, cancer progression and metastasis. The compounds and medical uses thereof show therapeutic efficacy in the treatment of subjects with elevated levels of MACC1. The invention relates to methods for the inhibition of MACC1-expression and for the medical treatment of subjects in early stages of cancer progression, in particular solid cancers, such as stage I or II colorectal or pancreatic cancer.