8'-(azepanium-1-ylmethyl)-6-chloro-2,2'-dioxo-2H,2'H-3,4'-bichromen-7'-olate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 8'-(azepanium-1-ylmethyl)-6-chloro-2,2'-dioxo-2H,2'H-3,4'-bichromen-7'-olate
• 英文别名: 8-(azepan-1-ium-1-ylmethyl)-4-(6-chloro-2-oxochromen-3-yl)-2-oxochromen-7-olate
• 化学式: C25H22ClNO5
• 分子量: 451.9
• InChiKey: IXPSNRWNPVNYOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• SMALL COMPOUNDS TARGETING TACC3
  申请人：JAPANESE FOUNDATION FOR CANCER RESEARCH

  公开号：US20150111888A1

  公开（公告）日：2015-04-23

  The present invention provides a small compound targeting at TACC3. The present invention further provides a drug, particularly, an anticancer agent, comprising the small compound targeting at TACC3. A compound represented by the general formula (I) or a pharmaceutically acceptable salt, solvate, or ester derivative thereof binds to TACC3 and inhibits cell growth. Thus, these compounds can be used as drugs, particularly, anticancer agents.
• US9630953B2
  申请人：——

  公开号：US9630953B2

  公开（公告）日：2017-04-25