N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methylpyrazine-2-carboxamide;3-(diaminomethylidene)-1,1-dimethylguanidine | 614753-49-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methylpyrazine-2-carboxamide;3-(diaminomethylidene)-1,1-dimethylguanidine
• CAS: 614753-49-0
• 化学式: C25H38N10O4S
• 分子量: 574.7
• InChiKey: JUPHQTXEKOAHOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.83
• 重原子数：
  40
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  230
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• COMPOSITE PRODUCT CONTAINING LIMONIN COMPOUND AND BIGUANIDE COMPOUND
  申请人：Zhejiang Yangshengtang Institute Of Natural Medication Co., Ltd.

  公开号：EP3666267A1

  公开（公告）日：2020-06-17

  The present invention relates to a combination product comprising a limonoid compound (or a pharmaceutically acceptable derivative, ester, stereoisomer, salt or prodrug thereof), and a biguanide compound (e.g., metformin, metformin hydrochloride, buformin, and phenformin). The present invention further relates to a use of the combination product for prevention and/or treatment of a disease associated with diabetes, for lipid-lowering and weight-loss, and the like.

  本发明涉及一种复方制剂，包括一种柠檬酸类化合物（或其药学上可接受的衍生物、酯、立体异构体、盐或原药）和一种双胍类化合物（如二甲双胍、盐酸二甲双胍、布福明和苯福明）。本发明进一步涉及组合产品在预防和/或治疗糖尿病相关疾病、降脂减肥等方面的用途。
• Methods of screening for caloric restriction mimetics and reproducing effects of caloric restriction
  申请人：——

  公开号：US20040180003A1

  公开（公告）日：2004-09-16

  A method for searching for a compound that mimics the effects induced by a caloric restriction (CR) program. The method comprises administering a CR diet program to a first group of mammals for a predetermined amount of time and administering a dosage of at least one compound to a second group of mammals for a term which is less than or equal to the predetermined amount of time. The method further comprises assessing changes in gene expression levels, levels of nucleic acids, proteins, or protein activity levels and determining whether the compound mimics effects induced by the CR diet program.

  一种寻找可模仿热量限制（CR）方案诱导效应的化合物的方法。该方法包括在预定时间内对第一组哺乳动物实施热量限制饮食计划，并在小于或等于预定时间的期限内对第二组哺乳动物实施至少一种化合物的剂量。该方法还包括评估基因表达水平、核酸水平、蛋白质水平或蛋白质活性水平的变化，并确定化合物是否能模拟 CR 饮食方案诱导的效果。
• METHODS OF EVALUATING CALORIC RESTRICTION AND IDENTIFYING CALORIC RESTRICTION MIMETICS
  申请人：The Regents of the University of California

  公开号：EP1601949A2

  公开（公告）日：2005-12-07
• EP1601949A4
  申请人：——

  公开号：EP1601949A4

  公开（公告）日：2007-07-18
• COMBINATION PRODUCT CONTAINING LIMONOID COMPOUND AND BIGUANIDE COMPOUND
  申请人：ZHEJIANG YANGSHENGTANG INSTITUTE OF NATURAL MEDICATION CO., LTD.

  公开号：US20220125757A1

  公开（公告）日：2022-04-28

  The present invention relates to a combination product comprising a limonoid compound (or a pharmaceutically acceptable derivative, ester, stereoisomer, salt or prodrug thereof), and a biguanide compound (e.g., metformin, metformin hydrochloride, buformin, and phenformin). The present invention further relates to a use of the combination product for prevention and/or treatment of a disease associated with diabetes, for lipid-lowering and weight-loss, and the like.