2-(4-Hydroxy-3-methoxyphenyl)-6-[2-(4-hydroxy-3-methoxyphenyl)ethenyl]-2,3-dihydropyran-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 2-(4-Hydroxy-3-methoxyphenyl)-6-[2-(4-hydroxy-3-methoxyphenyl)ethenyl]-2,3-dihydropyran-4-one
• 英文别名: 2-(4-hydroxy-3-methoxyphenyl)-6-[2-(4-hydroxy-3-methoxyphenyl)ethenyl]-2,3-dihydropyran-4-one
• 化学式: C₂₁H₂₀O₆
• 分子量: 368.4
• InChiKey: IZLBLUIBVMGMIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Method for the preparation of a 1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione system in polysorbates for the formation of micelles in an aqueous medium aimed at the properties of the bioavailability of curcuminoids
  申请人：Astudillo De La Vega Horacio

  公开号：US20210060166A1

  公开（公告）日：2021-03-04

  The invention relates to the preparation of a mixture of 1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione in polysorbates that allows the formation of micelles in water loaded with 1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione. With the developed formulation it is proposed to avoid bioavailability problems of this molecule, allowing to better demonstrate its benefits directed to systemic therapeutic effects, for example, anti-inflammatory drugs, and to reduce the use of drugs that cause direct or indirect irritation to the gastrointestinal mucosa, kidney damage, Cushing syndrome and/or immunosuppression.