6α-acetoxy-4,5α-epoxy-17-methyl-morphin-7-en-3-ol | 29593-26-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 6α-acetoxy-4,5α-epoxy-17-methyl-morphin-7-en-3-ol
• 英文别名: 6-Monoacetyl-morphin；O6-Acetylmorphin；6-Acetylmorphin；O⁶-acetyl-morphine；6-Monoacetylmorphine；(9-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl) acetate
• CAS: 29593-26-8
• 化学式: C₁₉H₂₁NO₄
• 分子量: 327.38
• InChiKey: JJGYGPZNTOPXGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] 6-ACETYLMORPHINE ANALOGS, AND METHODS FOR THEIR SYNTHESIS AND USE<br/>[FR] ANALOGUES DE 6-ACÉTYLMORPHINE ET LEURS PROCÉDÉS DE SYNTHÈSE ET D'UTILISATION
  申请人：ALERE SAN DIEGO INC

  公开号：WO2014152657A1

  公开（公告）日：2014-09-25

  The present invention relates to novel 6-acetylmorphine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.

  本发明涉及新型6-乙酰吗啡类似物，以及它们的合成和使用方法。这些类似物旨在提供便利的连接化学方法，在温和条件下将其耦合到靶蛋白质、多肽、固相或可检测标记上。
• [EN] HEROIN HAPTENS, IMMUNOCONJUGATES AND RELATED USES<br/>[FR] HAPTÈNES D'HÉROÏNE, IMMUNOCONJUGUÉS ET UTILISATIONS ASSOCIÉES
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2013095321A1

  公开（公告）日：2013-06-27

  The present invention provides novel heroin hapten compounds and heroin immunoconjugates which can be used for in vivo production of antibodies that specifically bind to heroin and its psychoactive metabolites. The invention also provides methods of using vaccines comprising the heroin immunoconjugates in active or passive immunization protocols. The compositions and methods of the invention are useful for prevention and treatment of heroin addiction.

  本发明提供了新型海洛因半抗原化合物和海洛因免疫结合物，可用于体内产生特异性结合海洛因及其精神活性代谢物的抗体。本发明还提供了使用包含海洛因免疫结合物的疫苗进行主动或被动免疫方案的方法。本发明的组合物和方法对于预防和治疗海洛因成瘾是有用的。
• Opiate analogs selective for the delta -opioid receptor
  申请人：The Curators of the University of Missouri

  公开号：US20040122230A1

  公开（公告）日：2004-06-24

  Novel compounds which selectively bind to the &dgr;-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the &dgr;-opioid receptor have shown promise in providing enhanced analgesis without the addictive properties, the compounds of the present invention are better than morphine, naltrindole (NTI), spiroindanyloxymorphone (SIOM), and other known &mgr;-opioid receptor selectors as analgesics.

  我们设计出了能选择性结合阿片受体的新型化合物。这些化合物具有更高的选择性、更好的水（血液）溶解性以及更高的镇痛治疗价值。由于对&dgr;-阿片受体具有选择性的激动剂有望提供更强的镇痛效果，但不会成瘾，因此本发明的化合物作为镇痛剂优于吗啡、纳尔吲哚（NTI）、螺茚氧吗啡酮（SIOM）和其他已知的&mgr;-阿片受体选择剂。
• METHOD FOR DETERMINATION OF DRUGS OF ABUSE IN BIOLOGICAL SAMPLES
  申请人：Varian, Inc.

  公开号：EP1027609A2

  公开（公告）日：2000-08-16
• INHIBITION OF ERK TO REDUCE OR PREVENT TOLERANCE TO AND DEPENDENCE ON OPIOID ANALGESICS
  申请人：Board of Regents,The University of Texas System

  公开号：EP1377279A2

  公开（公告）日：2004-01-07

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