(2-pyrrolidino-ethyl)-urea | 98430-77-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (2-pyrrolidino-ethyl)-urea
• 英文别名: (2-Pyrrolidino-aethyl)-harnstoff；2-Pyrrolidin-1-ylethylurea
• CAS: 98430-77-4
• 化学式: C₇H₁₅N₃O
• 分子量: 157.216
• InChiKey: IJYOKSVMARLIQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  58.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 (2-bromo-ethyl)-urea 在 乙醇 作用下， 生成 (2-pyrrolidino-ethyl)-urea
  参考文献：
  名称：

  Chiti; Selleri, Farmaco, Edizione Scientifica, 1958, vol. 13, p. 261,282

  摘要：

  DOI：

文献信息

• NITROGEN-CONTAINING COMPOUNDS SUITABLE FOR USE IN THE PRODUCTION OF POLYURETHANES
  申请人：Evonik Degussa GmbH

  公开号：US20180194889A1

  公开（公告）日：2018-07-12

  The present invention provides for the use of nitrogen compounds of formula (I) and/or of corresponding quaternized and/or protonated compounds for production of polyurethanes, compositions containing these compounds and polyurethane systems, especially polyurethane foams, which have been obtained using the compounds.

  本发明提供了使用式(I)的氮化合物和/或相应的季铵化和/或质子化化合物用于生产聚氨酯、含有这些化合物的组合物和聚氨酯体系的方法，特别是使用这些化合物获得的聚氨酯泡沫。
• [EN] CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS<br/>[FR] CERTAINES ENTITÉS CHIMIQUES, COMPOSITIONS ET PROCÉDÉS
  申请人：NEUPHARMA INC

  公开号：WO2013165924A1

  公开（公告）日：2013-11-07

  Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.

  描述了新化合物、药物组合物和治疗癌症的方法的化学实体。
• Heterocyclic compounds
  申请人：Leriche Caroline

  公开号：US20120041195A1

  公开（公告）日：2012-02-16

  The invention is directed to certain novel compounds, methods for producing them and methods for treating or ameliorating a kinase-mediated disorder. More particularly, this invention is directed to substituted triazolopyridine compounds useful as selective kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase-mediated disorder. In particular, the methods relate to treating or ameliorating a kinase-mediated disorder including cardiovascular diseases, diabetes, diabetes-associated disorders, inflammatory diseases, immunological disorders, cancer and diseases of the eye such as retinopathies or macular degeneration or other vitreoretinal diseases, and the like.

  本发明涉及某些新型化合物，制备它们的方法以及治疗或改善激酶介导的疾病的方法。更具体地说，本发明涉及取代的三唑吡啶化合物，可用作选择性激酶抑制剂，制备这种化合物的方法以及治疗或改善激酶介导的疾病的方法。特别是，这些方法涉及治疗或改善激酶介导的疾病，包括心血管疾病、糖尿病、糖尿病相关疾病、炎症性疾病、免疫性疾病、癌症以及眼部疾病，如视网膜病变、黄斑变性或其他玻璃体视网膜疾病等。
• Nitrogen-containing compounds suitable for use in the production of polyurethanes
  申请人：Evonik Operations GmbH

  公开号：US10793662B2

  公开（公告）日：2020-10-06

  The present invention provides for the use of nitrogen compounds of formula (I) and/or of corresponding quaternized and/or protonated compounds for production of polyurethanes, compositions containing these compounds and polyurethane systems, especially polyurethane foams, which have been obtained using the compounds.

  本发明提供了使用式（I）含氮化合物和/或相应的季铵化和/或质子化化合物生产聚氨酯、含有这些化合物的组合物以及使用这些化合物获得的聚氨酯体系，特别是聚氨酯泡沫。
• CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
  申请人：Neupharma, Inc.

  公开号：EP2852285A1

  公开（公告）日：2015-04-01