5-(5-p-Tolyl-furan-2-ylmethylene)-pyrimidine-2,4,6-trione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-(5-p-Tolyl-furan-2-ylmethylene)-pyrimidine-2,4,6-trione
• 英文别名: 5-[[5-(4-methylphenyl)furan-2-yl]methylidene]-1,3-diazinane-2,4,6-trione
• 化学式: C₁₆H₁₂N₂O₄
• mdl: MFCD01816856
• 分子量: 296.28
• InChiKey: JTKIZRWVKQEKAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  88.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• NS1 protein inhibitors
  申请人：Roth Michael

  公开号：US20090170840A1

  公开（公告）日：2009-07-02

  The present invention generally relates to compounds to treat viral infections and methods of their use. In particular, compounds of the present invention inhibit the activity of NS1 protein, thereby mitigating viral infection and, in particular, influenza virus infection. Accordingly, NS1 protein inhibitors and methods of treatment that employ such inhibitors are contemplated by the present invention.
• NS1 PROTEIN INHIBITORS
  申请人：Roth Michael

  公开号：US20120178749A1

  公开（公告）日：2012-07-12

  The present invention generally relates to compounds to treat viral infections and methods of their use. In particular, compounds of the present invention inhibit the activity of NS1 protein, thereby mitigating viral infection and, in particular, influenza virus infection. Accordingly, NS1 protein inhibitors and methods of treatment that employ such inhibitors are contemplated by the present invention.
• US8119656B2
  申请人：——

  公开号：US8119656B2

  公开（公告）日：2012-02-21