β,γ-dipalmitoyl-α-phosphatidylserine | 40290-43-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: β,γ-dipalmitoyl-α-phosphatidylserine
• 英文别名: 1,2-dipalmitoyl-sn-glycero-3-phosphatidylserine；1,2-dipalmitoyl-sn-glycero-3-phosphoserine；1,2-Dipalmitoyl-sn-glycero-3-phosphoserin；Dipalmitoylphosphatidylserin；1,2-Di-O-palmitoyl-glyceryl-3-O-phosphoryl-O-(DL-serin)；rac-1,2-dipalmitoylglycero-3-phospho-L-serine；dipalmitoyl phosphatidylserine；1,2-Dipalmitoyl-rac-glycero-3-phospho-L-serine；2-amino-3-[2,3-di(hexadecanoyloxy)propoxy-hydroxyphosphoryl]oxypropanoic acid
• CAS: 40290-43-5
• 化学式: C₃₈H₇₄NO₁₀P
• 分子量: 735.98
• InChiKey: KLFKZIQAIPDJCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  50
• 可旋转键数：
  40
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  172
• 氢给体数：
  3
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  [2-hexadecanoyloxy-3-[[3-oxo-3-phenylmethoxy-2-(phenylmethoxycarbonylamino)propoxy]-phenoxyphosphoryl]oxypropyl] hexadecanoate 在 platinum(IV) oxide 氢气 作用下， 生成 β,γ-dipalmitoyl-α-phosphatidylserine
  参考文献：
  名称：

  Kabanova,M.A. et al., Journal of general chemistry of the USSR, 1973, vol. 43, p. 189 - 194

  摘要：

  DOI：

文献信息

• [EN] COMPOSITIONS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS<br/>[FR] COMPOSITIONS ET PROCÉDÉS PERMETTANT D'ADMINISTRER DES AGENTS THÉRAPEUTIQUES
  申请人：MODERNATX INC

  公开号：WO2017099823A1

  公开（公告）日：2017-06-15

  This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

  这项披露提供了改进的基于脂质的组合物，包括脂质纳米粒子组合物，以及它们用于体内传递药剂的方法，包括核酸和蛋白质。这些组合物不受加速血清清除的影响，并且它们在体内具有改进的毒性特性。
• [EN] FLUOROUS METAL CHELATES COMPOSITIONS<br/>[FR] COMPOSITIONS DE CHÉLATES MÉTALLIQUES FLUORITIQUES
  申请人：THE REGENTS OF THE UNIVEFISITY OF CALIFORNIA

  公开号：WO2020118307A1

  公开（公告）日：2020-06-11

  This disclosure provides compositions of SALTAME core containing compounds and associated methods for use in tracking cells by magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), and related methods.

  这份披露提供了含有盐核心的化合物组合物以及用于通过核磁共振成像（MRI）、计算机断层扫描（CT）、正电子发射断层扫描（PET）和相关方法追踪细胞的方法。
• MARTIN, STEPHEN F.;JOSEY, JOHN A., TETRAHEDRON LETT., 29,(1988) N 30, C. 3631-3634
  作者：MARTIN, STEPHEN F.、JOSEY, JOHN A.

  DOI：——

  日期：——
• Method and device for producing optimized lipid-based micro/nano-bubbles
  申请人：Trust Bio-sonics Inc.

  公开号：EP2799087B1

  公开（公告）日：2020-03-11
• COMPOSITIONS AND METHODS FOR DELIVERY OF AGENTS
  申请人：ModernaTX, Inc.

  公开号：US20180028664A1

  公开（公告）日：2018-02-01

  This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.