2-Methylbut-2-enedioyl dichloride | 20537-97-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: 2-Methylbut-2-enedioyl dichloride
• CAS: 20537-97-7
• 化学式: C₅H₄Cl₂O₂
• 分子量: 166.99
• InChiKey: LATZCKQPCAXJJJ-UHFFFAOYSA-N

物化性质

• 沸点：
  219.6±23.0 °C(Predicted)
• 密度：
  1.374±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• MONOMETHYLFUMARATE PRODRUG COMPOSITIONS
  申请人：Alkermes Pharma Ireland Limited

  公开号：US20160228376A1

  公开（公告）日：2016-08-11

  The present invention provides pharmaceutical compositions comprising compounds of Formula (I), and methods of treating neurological disorders comprising administering to a subject in need thereof a pharmaceutical composition comprising a compound of Formula (I).

  本发明提供了包含化合物I式的药物组合物，并且提供了治疗神经系统疾病的方法，包括向需要的受试者施用包含化合物I式的药物组合物。
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF MULTIPLE SCLEROSIS
  申请人：Cellix Bio Private Limited

  公开号：US20160152553A1

  公开（公告）日：2016-06-02

  The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing multiple sclerosis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of multiple sclerosis and psoriasis.

  该发明涉及公式I和公式II的化合物或其药用可接受的盐，以及其多晶形、溶剂合物、对映体、立体异构体和水合物。包括公式I或公式II化合物的有效量的药物组合物；以及用于治疗或预防多发性硬化的方法可以制成口服、颊部、直肠、局部、经皮、经粘膜、静脉、肠道、糖浆或注射剂的制剂。这些组合物可用于治疗多发性硬化和银屑病。
• PRODRUGS OF FUMARATES AND THEIR USE IN TREATING VARIOUS DISEASES
  申请人：Alkermes Pharma Ireland Limited

  公开号：US20160137660A1

  公开（公告）日：2016-05-19

  The present invention provides compounds of formula (I), wherein: R 1 is unsubstituted C 1 -C 6 alkyl; L a is substituted or unsubstituted C 1 -C 6 alkyl linker, substituted or unsubstituted C 3 -C 10 carbocycle, substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, or substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S; and R 2 and R 3 are each, independently, H, substituted or unsubstituted C 1 -C 6 alkyl, or substituted or unsubstituted C 6 -C 10 aryl; or alternatively, R 2 and R 3 , together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S or a substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S. The invention also provides pharmaceutical compositions and methods for treating neurological diseases, such as multiple sclerosis.

  本发明提供式（I）的化合物，其中：R1是未取代的C1-C6烷基；La是取代或未取代的C1-C6烷基连接物，取代或未取代的C3-C10碳环，包含一个或两个5-或6-成员环和1-4个从N，O和S中选择的杂原子的取代或未取代的杂环，或者是取代或未取代的含有一个或两个5-或6-成员环和1-4个从N，O和S中选择的杂原子的取代或未取代的杂芳基；R2和R3各自独立地是H，取代或未取代的C1-C6烷基，或取代或未取代的C6-C10芳基；或者，R2和R3与它们附着的氮原子一起形成取代或未取代的杂芳基，其中包括一个或两个5-或6-成员环和1-4个从N，O和S中选择的杂原子，或取代或未取代的含有一个或两个5-或6-成员环和1-4个从N，O和S中选择的杂原子的杂环。本发明还提供用于治疗神经系统疾病，如多发性硬化症的药物组合物和方法。
• PRODRUGS OF MONOMETHYL FUMARATE (MMF)
  申请人：RATIOPHARM GMBH

  公开号：US20150299103A1

  公开（公告）日：2015-10-22

  The present invention relates to novel compounds for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.

  本发明涉及新型化合物作为药物的用途。具体而言，本发明涉及新型丙烯酸单甲酯（MMF）的前药，适用于药物，优选用于治疗和/或预防全身性疾病，自身免疫性疾病，炎症性疾病，例如多发性硬化和牛皮癣。
• Process for preparing amide derivatives from halomines and acid halides
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0541966A2

  公开（公告）日：1993-05-19

  This invention provides a process for preparing amide derivatives of acids by the reaction of haloamines and acid halides. Melamine derived acid amides are prepared by reaction of trichloro and hexachloromelamines with chloroformates and acid chlorides. The by-product chlorine may be recycled in this process. Amides, carbamates, sulfonamides, phosphoramides, and related amide derivatives may be prepared by the novel process of the invention.

  本发明提供了一种通过卤胺和酸卤化物反应制备酸酰胺衍生物的工艺。 三氯和六氯甲胺与氯甲酸酯和酸性氯化物反应制备三聚氰胺衍生酸酰胺。副产品氯可以在此过程中回收利用。 酰胺、氨基甲酸酯、磺酰胺、磷酰胺和相关的酰胺衍生物可通过本发明的新工艺制备。