Uridine diphosphate-N-acetylgalactosamine | 7277-98-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: Uridine diphosphate-N-acetylgalactosamine
• 英文别名: [3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl] [[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate
• CAS: 7277-98-7
• 化学式: C₁₇H₂₇N₃O₁₇P₂
• 分子量: 607.4
• InChiKey: LFTYTUAZOPRMMI-UHFFFAOYSA-N

物化性质

• 密度：
  1.86±0.1 g/cm3(Predicted)
• 物理描述：
  Solid
• 碰撞截面：
  216.2 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]

计算性质

• 辛醇/水分配系数(LogP)：
  -6.6
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  300
• 氢给体数：
  9
• 氢受体数：
  17

文献信息

• ENZYMATIC METHOD FOR PREPARATION OF UDP-GLCNAC
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3819382A1

  公开（公告）日：2021-05-12

  The present invention relates to an enzyme-catalyzed process for producing UDP-N-acetyl-α-D-glucosamine (UDP-GlcNAc) from low-cost substrates uridine monophosphate and N-acetyl-D glucosamine in a single reaction mixture with immobilized or preferably co-immobilized enzymes. Further, said process may be adapted to produce GlcNAcylated molecules and biomolecules including saccharides, particularly human milk oligosaccharides (HMO), proteins, peptides, glycoproteins, particularly antibodies, or glycopeptides, and bioconjugates, particularly carbohydrate conjugate vaccines and antibody-drug conjugates.

  本发明涉及一种在单一反应混合物中用固定化酶或优选共固定化酶从低成本底物单磷酸尿苷和N-乙酰-D-葡糖胺生产UDP-N-乙酰-α-D-葡糖胺（UDP-GlcNAc）的酶催化过程。此外，所述工艺还可用于生产 GlcNAcylated 分子和生物大分子，包括糖类，特别是人乳低聚糖 (HMO)、蛋白质、肽、糖蛋白，特别是抗体或糖肽，以及生物共轭物，特别是碳水化合物共轭疫苗和抗体-药物共轭物。
• GLYCOPEGYLATED FOLLICLE STIMULATING HORMONE
  申请人：Novo Nordisk A/S

  公开号：US20150111245A1

  公开（公告）日：2015-04-23

  The invention provides conjugates between follicle stimulating hormone and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
• US8633157B2
  申请人：——

  公开号：US8633157B2

  公开（公告）日：2014-01-21
• US9187546B2
  申请人：——

  公开号：US9187546B2

  公开（公告）日：2015-11-17