fusidienol | 157173-61-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: fusidienol
• 英文别名: 7-hydroxy-3-(hydroxymethyl)-6-oxo-6H-oxepino[2,3-b][1]benzopyran-5-carboxylic acid methyl ester；methyl 7-hydroxy-3-(hydroxymethyl)-6-oxooxepino[2,3-b]chromene-5-carboxylate
• CAS: 157173-61-0
• 化学式: C₁₆H₁₂O₇
• 分子量: 316.267
• InChiKey: LJNGMSGIOXTZLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N,O-双(三甲基硅烷基)三氟乙酰胺 、 fusidienol 在 吡啶 作用下， 生成 11-Oxo-1-trimethylsilanyloxy-8-trimethylsilanyloxymethyl-11H-5,6-dioxa-cyclohepta[b]naphthalene-10-carboxylic acid methyl ester
  参考文献：
  名称：

  Fusidienol: A novel inhibitor of Ras farnesyl-protein transferase from Fusidium griseum

  摘要：

  Ras (p21) protein is frequently found mutated in human cancers and must be farnesylated by farnesyl protein-transferase (FPTase) to achieve cell-transforming activity. Our continued search for inhibitors of FPTase as potential cancer chemotherapeutics led to the isolation of fusidienol from extracts of the fungus Fusidium griseum. Fusidienol is a novel and potent oxygen-containing [7/6/6] tricyclic heterocycle.

  DOI：

  10.1016/s0040-4039(00)76943-7

文献信息

• US5436263A
  申请人：——

  公开号：US5436263A

  公开（公告）日：1995-07-25
• Fusidienol: A novel inhibitor of Ras farnesyl-protein transferase from Fusidium griseum
  作者：Sheo B Singh、E.Tracy Jones、Michael A. Goetz、Gerald F. Bills、Mary Nallin-Omstead、Rosalind G. Jenkins、Russell B. Lingham、Keith C. Silverman、Jackson B. Gibbs

  DOI：10.1016/s0040-4039(00)76943-7

  日期：1994.7

  Ras (p21) protein is frequently found mutated in human cancers and must be farnesylated by farnesyl protein-transferase (FPTase) to achieve cell-transforming activity. Our continued search for inhibitors of FPTase as potential cancer chemotherapeutics led to the isolation of fusidienol from extracts of the fungus Fusidium griseum. Fusidienol is a novel and potent oxygen-containing [7/6/6] tricyclic heterocycle.