N-carbobenzoxy-D-α-metoxyglycine | 134357-47-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-carbobenzoxy-D-α-metoxyglycine
• 英文别名: (2R)-2-methoxy-2-(phenylmethoxycarbonylamino)acetic acid
• CAS: 134357-47-4
• 化学式: C₁₁H₁₃NO₅
• 分子量: 239.228
• InChiKey: GVOGBZLADZSQHE-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Phenylalanyl-glycinanhydrid 、 N-carbobenzoxy-D-α-metoxyglycine 在 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 生成
  参考文献：
  名称：

  Optical resolution of N-carbobenzoxy-α-methoxyglycine

  摘要：

  Optical resolution of racemic N-carbobenzoxy-alpha-methoxyglycine using D/L-phenylalaninol or (1S,2S)-2-amino-1-phenyl-1,3-propanediol afforded (+)- and (-)-enantiomers, to which D- and L-configurations, respectively, were assigned based on the H-1 NMR data and biological activity of dermorphin N-terminal tetrapeptide analogs.

  DOI：

  10.1016/s0957-4166(00)86033-4
• 作为产物：
  描述：

  N-carbobenzoxy-D/L-α-metoxyglycine 生成 N-carbobenzoxy-D-α-metoxyglycine
  参考文献：
  名称：

  Optical resolution of N-carbobenzoxy-α-methoxyglycine

  摘要：

  Optical resolution of racemic N-carbobenzoxy-alpha-methoxyglycine using D/L-phenylalaninol or (1S,2S)-2-amino-1-phenyl-1,3-propanediol afforded (+)- and (-)-enantiomers, to which D- and L-configurations, respectively, were assigned based on the H-1 NMR data and biological activity of dermorphin N-terminal tetrapeptide analogs.

  DOI：

  10.1016/s0957-4166(00)86033-4

文献信息

• Optical resolution of N-carbobenzoxy-α-methoxyglycine
  作者：Masao Kawai、Yoshimasa Omori、Hatsuo Yamamura、Yasuo Butsugan

  DOI：10.1016/s0957-4166(00)86033-4

  日期：1992.8

  Optical resolution of racemic N-carbobenzoxy-alpha-methoxyglycine using D/L-phenylalaninol or (1S,2S)-2-amino-1-phenyl-1,3-propanediol afforded (+)- and (-)-enantiomers, to which D- and L-configurations, respectively, were assigned based on the H-1 NMR data and biological activity of dermorphin N-terminal tetrapeptide analogs.