N,N,N',N'-tetrakis(3-aminopropyl)-p-xylylenediamine | 189076-31-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N,N',N'-tetrakis(3-aminopropyl)-p-xylylenediamine
• 英文别名: 1,4-bis(N,N-bis(3-aminopropyl)aminomethyl)benzene；N'-(3-aminopropyl)-N'-[[4-[[bis(3-aminopropyl)amino]methyl]phenyl]methyl]propane-1,3-diamine
• CAS: 189076-31-1
• 化学式: C₂₀H₄₀N₆
• 分子量: 364.578
• InChiKey: FGIXKMMIIPMYFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  26
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  111
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N,N,N',N'-tetrakis(3-aminopropyl)-p-xylylenediamine 生成
  参考文献：
  名称：

  一系列新的[12] aneN 3型大环的合成和表征。两个无金属质子化的配体的结构

  摘要：

  描述了具有[12] aneN 3合成子和不同间隔基的单位和双位配体家族的合成。还报道了它们中的两个通过X射线衍射的表征。

  DOI：

  10.1016/s0040-4039(97)00241-4
• 作为产物：
  描述：

  1,4-bis(N,N-bis(2-cyanoethyl)aminomethyl)benzene 在 Raney Co 氢气 作用下， 以 1,4-二氧六环 为溶剂， 180.0 ℃ 、9.0 MPa 条件下， 反应 2.0h， 生成 N,N,N',N'-tetrakis(3-aminopropyl)-p-xylylenediamine
  参考文献：
  名称：

  EP1840127

  摘要：

  公开号：

文献信息

• [EN] 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES<br/>[FR] DERIVES DE 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE RENINE DANS LE TRAITEMENT DE L'HYPERTENSION, DE MALADIES CARDIOVASCULAIRES OU RENALES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2003093267A1

  公开（公告）日：2003-11-13

  The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin.

  该发明涉及新型3,9-二氮杂双环[3.3.1]壬烯衍生物（I）及相关化合物，以及它们作为药物组合物中活性成分的用途。该发明还涉及相关方面，包括制备这些化合物的过程、含有这些化合物中的一个或多个的药物组合物，尤其是它们作为肾素抑制剂的用途。
• Polyamine Derivative and Polyol Derivative
  申请人：Mita Naruyoshi

  公开号：US20080230743A1

  公开（公告）日：2008-09-25

  A novel polyamine derivative, or polyol derivative, having a piperidylaminotriazine skeleton; salts of such compounds; a process for producing them; an organic material stabilizer comprising any of such compounds; a method of stabilizing an organic material; and a stabilized organic material. Compounds of the general formula: (1) (wherein X is N(R 4 ) or an oxygen atom; R 1 is an n-valent hydrocarbon group; R 2 is a hydrogen atom or an alkyl; R 3 is a hydrogen atom, an alkyl, an alkoxy or an acyl; R 4 is a hydrogen atom or an alkyl; and n is an integer of 3 to 16) are effective in the stabilization of an organic material against deterioration by light, heat, oxygen, ozone and electromagnetic waves, such as X-rays and γ-rays.

  一种新型的聚胺衍生物或聚醇衍生物，具有哌啶基氨基三嗪骨架；这些化合物的盐；一种生产它们的过程；包括上述任何一种化合物的有机材料稳定剂；一种稳定有机材料的方法；以及稳定的有机材料。通式（1）的化合物：（其中X是N（R4）或氧原子；R1是n价碳氢基团；R2是氢原子或烷基；R3是氢原子，烷基，烷氧基或酰基；R4是氢原子或烷基；n是3至16的整数）对于稳定有机材料免受光，热，氧，臭氧和电磁波（如X射线和γ射线）的损害非常有效。
• Polyamine derivative and polyol derivative
  申请人：BASF SE

  公开号：US08076478B2

  公开（公告）日：2011-12-13

  A novel polyamine derivative, or polyol derivative, having a piperidylaminotriazine skeleton; salts of such compounds; a process for producing them; an organic material stabilizer comprising any of such compounds; a method of stabilizing an organic material; and a stabilized organic material. Compounds of the general formula: (1) (wherein X is N(R4) or an oxygen atom; R1 is an n-valent hydrocarbon group; R2 is a hydrogen atom or an alkyl; R3 is a hydrogen atom, an alkyl, an alkoxy or an acyl; R4 is a hydrogen atom or an alkyl; and n is an integer of 3 to 16) are effective in the stabilization of an organic material against deterioration by light, heat, oxygen, ozone and electromagnetic waves, such as X-rays and γ-rays.

  一种新型的聚胺衍生物或聚醇衍生物，具有哌啶基氨基三嗪骨架；这些化合物的盐；一种生产它们的过程；包括任何这些化合物的有机材料稳定剂；一种稳定有机材料的方法；以及稳定的有机材料。一般式化合物：(1)（其中X是N（R4）或氧原子；R1是n价碳氢基团；R2是氢原子或烷基；R3是氢原子，烷基，烷氧基或酰基；R4是氢原子或烷基；n是3至16的整数）对于通过光，热，氧气，臭氧和电磁波（如X射线和γ射线）的恶化稳定有机材料有效。
• POLYAMINE DERIVATIVE AND POLYOL DERIVATIVE
  申请人：MITA NARUYOSHI

  公开号：US20120053270A1

  公开（公告）日：2012-03-01

  A novel polyamine derivative, or polyol derivative, having a piperidylaminotriazine skeleton; salts of such compounds; a process for producing them; an organic material stabilizer comprising any of such compounds; a method of stabilizing an organic material; and a stabilized organinc material. Compounds of the general formula: (1) (wherein X is N(R 4 ) or an oxygen atom; R 1 is an n-valent hydrocarbon group; R 2 is an hydrogen atom or an alkyl; R 3 is a hydrogen atom, an alkyl, an alkoxy or an acyl; R 4 is a hydrogen atom or an alkyl; and n is an integer of 3 to 16) are effective in the stabilization of an organic material against deterioration by light, heat, oxygen, ozone and electromagnetic waves, such as X-rays and γ-rays.

  一种新型的聚胺衍生物或聚醇衍生物，具有哌啶基氨基三嗪骨架；这些化合物的盐；一种生产它们的过程；包括任何此类化合物的有机材料稳定剂；一种稳定有机材料的方法；以及一种稳定的有机材料。通式为（1）的化合物：（其中X是N（R4）或氧原子；R1是n价碳氢基团；R2是氢原子或烷基；R3是氢原子、烷基、烷氧基或酰基；R4是氢原子或烷基；n是3到16的整数）对于通过光、热、氧、臭氧和电磁波（如X射线和γ射线）恶化的有机材料的稳定化是有效的。
• Polyamine derivative
  申请人：BASF SE

  公开号：EP2484677A1

  公开（公告）日：2012-08-08

  A compound represented by general formula (1) wherein X represents N(R4), R1 is a group selected from a general formula (2-2): wherein R5 represents a m-valent hydrocarbon group, provided that a nitrogen atom or an oxygen atom may be contained in the hydrocarbon group R5, m represents an integer of from 2 to 8 and d represents an integer of from 1 to 6, R2 represents a hydrogen atom or an alkyl group having from 1 to 9 carbon atoms, R3 represents a hydrogen atom, an alkyl group having from 1 to 9 carbon atoms, an alkoxy group having from 1 to 9 carbon atoms or an acyl group having from 2 to 9 carbon atoms, R4 represents a hydrogen atom or an alkyl group having from 1 to 9 carbon atoms and n represents an integer of from 3 to 16, or its salt is suitable as stabilizer for organic material.

  通式(1)代表的化合物 其中 X 代表 N(R4)，R1 是选自通式（2-2）的基团： 其中 R5 代表 m 价烃基，条件是烃基 R5 中可能含有氮原子或氧原子，m 代表 2 至 8 的整数，d 代表 1 至 6 的整数、 R2 代表氢原子或具有 1 至 9 个碳原子的烷基，R3 代表氢原子、具有 1 至 9 个碳原子的烷基、具有 1 至 9 个碳原子的烷氧基或具有 2 至 9 个碳原子的酰基，R4 代表氢原子或具有 1 至 9 个碳原子的烷基，n 代表 3 至 16 的整数、 或其盐类可用作有机材料的稳定剂。