2-Ethoxy-N,N-diethyl-2-phenylsulfanyl-acetamide | 136764-69-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-Ethoxy-N,N-diethyl-2-phenylsulfanyl-acetamide
• 英文别名: 2-ethoxy-N,N-diethyl-2-phenylsulfanylacetamide
• CAS: 136764-69-7
• 化学式: C₁₄H₂₁NO₂S
• 分子量: 267.392
• InChiKey: SCSWTAHMULIKFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  54.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙醇 、 N,N-diethyl-2-(phenylthio)acetamide 在 triethylamine tris(hydrogen fluoride) 作用下， 以 甲醇 为溶剂， 以73%的产率得到2-Ethoxy-N,N-diethyl-2-phenylsulfanyl-acetamide
  参考文献：
  名称：

  Electrolytic reactions of fluoro organic compounds. 9. Fluoride ion promoted anodic substitutions of chalcogeno compounds. 1. Regioselective anodic alkoxylation of sulfides

  摘要：

  Anodic alpha-alkoxylation of sulfides was remarkably promoted in the presence of fluoride ions: When Et3N.3HF was used as a supporting electrolyte, simple alkyl phenyl sulfides and sulfides bearing weak electron-withdrawing groups underwent anodic alkoxylation via fluorosulfonium ions as key intermediates in a unique Pummerer-type mechanism with reasonable or high yields for the first time.

  DOI：

  10.1021/jo00024a002

文献信息

• Electrolytic reactions of fluoro organic compounds. 9. Fluoride ion promoted anodic substitutions of chalcogeno compounds. 1. Regioselective anodic alkoxylation of sulfides
  作者：Toshio Fuchigami、Hidetoshi Yano、Akinori Konno

  DOI：10.1021/jo00024a002

  日期：1991.11

  Anodic alpha-alkoxylation of sulfides was remarkably promoted in the presence of fluoride ions: When Et3N.3HF was used as a supporting electrolyte, simple alkyl phenyl sulfides and sulfides bearing weak electron-withdrawing groups underwent anodic alkoxylation via fluorosulfonium ions as key intermediates in a unique Pummerer-type mechanism with reasonable or high yields for the first time.