2-[2-Amino-5-(3-methoxyphenoxy)-6-methylpyrimidin-4-yl]-5-methoxyphenol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-[2-Amino-5-(3-methoxyphenoxy)-6-methylpyrimidin-4-yl]-5-methoxyphenol
• 化学式: C₁₉H₁₉N₃O₄
• mdl: MFCD05702070
• 分子量: 353.4
• InChiKey: NIBVQCSJCPBPEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  99.7
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• INCREASED E-CADHERIN EXPRESSION OR ACTIVITY FOR THE TREATMENT OF INFLAMMATORY DISEASES
  申请人：The Cleveland Clinic Foundation

  公开号：US20220008402A1

  公开（公告）日：2022-01-13

  Provided herein are methods and systems employing agents that up-regulate E-cadherin, or E-cadherin agonists, for the treatment of inflammatory diseases, such as inflammatory bowel diseases (e.g., Crohn's disease). In certain embodiments, the agent employed is ML327, E-cadherin Up-regulator (ECU), or a compound of Formula I or II.