(1-Hydroxy-3-octadecanoyloxypropan-2-yl) icosa-5,8,11,14-tetraenoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: (1-Hydroxy-3-octadecanoyloxypropan-2-yl) icosa-5,8,11,14-tetraenoate
• 化学式: C₄₁H₇₂O₅
• 分子量: 645.0
• InChiKey: NSXLMTYRMFVYNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.3
• 重原子数：
  46
• 可旋转键数：
  36
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• N1- and N2-CARBAMOYL-1,2,3-TRIAZOLE SERINE HYDROLASE INHIBITORS AND METHODS
  申请人：Cravatt Benjamin

  公开号：US20140018318A1

  公开（公告）日：2014-01-16

  The present invention provides inhibitors of a wide variety of serine hydrolase enzymes. The inhibitors of the present invention are N1- and N2-carbamoyl-1,2,3-triazole compounds such as those of Formula (I): in which N1, N2, and N3 are the nitrogen atoms at positions 1, 2, and 3, respectively, of the triazole ring, and R 4 , R 5 , R 6 and R 7 in Formula (I) are as described herein. Methods of inhibiting serine hydrolase enzymes and methods of preparing carbamoyl-1,2,3-triazole compounds also are described.

  本发明提供了一种广泛的丝氨酸水解酶酶抑制剂。本发明的抑制剂是N1-和N2-氨基甲酰基-1,2,3-三唑化合物，例如公式（I）中的化合物：其中N1、N2和N3是三唑环的1、2和3位置的氮原子，公式（I）中的R4、R5、R6和R7如本文所述。还描述了抑制丝氨酸水解酶的方法和制备氨基甲酰基-1,2,3-三唑化合物的方法。
• PEPTIDYL DIACYLGLYCERIDES
  申请人：Therimunex Pharmaceuticals, Inc.

  公开号：EP2293809B1

  公开（公告）日：2019-05-15
• IMMUNOLOGICALLY ACTIVE LIPOPEPTIDES AND METHODS FOR USE THEREOF
  申请人：Thacker James Douglas

  公开号：US20120238491A1

  公开（公告）日：2012-09-20

  The present invention relates to the isolation and structure elucidation of 1-peptidyl-2-arachidonoyl-3-stearoyl glyceride (pDAG) as an active chemical entity in the caprine serum fraction, and the discovery of the innate immune modulating activity of pDAG as an endogenous damage associated molecular pattern
• US7608589B2
  申请人：——

  公开号：US7608589B2

  公开（公告）日：2009-10-27
• US9108930B2
  申请人：——

  公开号：US9108930B2

  公开（公告）日：2015-08-18