8-(2,4-dihydroxy-6-pentylphenoxy)-6-hydroxy-3-pentyl-1H-isochromen-1-one | 58005-58-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异香豆素及其衍生物
• 英文名称: 8-(2,4-dihydroxy-6-pentylphenoxy)-6-hydroxy-3-pentyl-1H-isochromen-1-one
• 英文别名: 8-(2,4-Dihydroxy-6-pentylphenoxy)-6-hydroxy-3-pentylisochromen-1-one
• CAS: 58005-58-6
• 化学式: C₂₅H₃₀O₆
• 分子量: 426.51
• InChiKey: NXAFAINHPNBMLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲酸 作用下， 生成 8-(2,4-dihydroxy-6-pentylphenoxy)-6-hydroxy-3-pentyl-1H-isochromen-1-one
  参考文献：
  名称：

  Asahina; Nogami, Chemische Berichte, 1934, vol. 67, p. 805

  摘要：

  DOI：

文献信息

• QUINOLIN-2,4-ONE DERIVATIVES FOR INHIBITING CHEMOKINE ACTIVITY
  申请人：Biokine Therapeutics Ltd.

  公开号：EP3741432A1

  公开（公告）日：2020-11-25

  Compounds for use in modulating a biological activity of a chemokine selected from MCP-1 and SDF-1, or for use in treating diseases and disorders associated with a biological activity of said chemokine, are provided herein. The compounds are collectively represented by Formulae Ia or Ib: wherein A, B D, E, G and R1-R5 are as defined in the specification.

  本文提供的化合物用于调节选自 MCP-1 和 SDF-1 的趋化因子的生物活性，或用于治疗与所述趋化因子的生物活性相关的疾病和失调。这些化合物统称为式 Ia 或式 Ib： 其中 A、B D、E、G 和 R1-R5 如说明书中所定义。
• Small molecules against cancer
  申请人：Biokine Therapeutics Ltd.

  公开号：US10646465B2

  公开（公告）日：2020-05-12

  Compounds capable of, or usable in, killing cancer cells, and/or modulating a biological activity of a chemokine, and/or inhibiting a kinase, and/or treating diseases and disorders associated with a biological activity of a chemokine and/or cell migration, and/or treating disease and disorders such as cancer and inflammatory diseases and disorders, are provided herein. The compounds are listed in Tables 2, 4 and 5, and/or are represented by Formulae I, IV, V and VI, as defined in the specification. Methods utilizing these compounds are also provided.

  本文提供的化合物能够或可用于杀死癌细胞，和/或调节趋化因子的生物活性，和/或抑制激酶，和/或治疗与趋化因子的生物活性和/或细胞迁移相关的疾病和紊乱，和/或治疗疾病和紊乱，如癌症和炎症性疾病和紊乱。这些化合物列于表 2、表 4 和表 5 中，和/或由式 I、式 IV、式 V 和式 VI 表示，如说明书中所定义。还提供了利用这些化合物的方法。
• Small molecules for inhibiting chemokine activity and/or cancer cells growth
  申请人：Biokine Therapeutics Ltd.

  公开号：US11129824B2

  公开（公告）日：2021-09-28

  Compounds capable of, or usable in, inducing death of cancer cells and/or modulating a biological activity of a chemokine e.g., cell migration, and/or treating diseases and disorders associated with a biological activity of a chemokine and/or cell migration, and/or inhibiting a kinase and/or in treating a disease or disorder associated with an activity of a kinase, such as cancer and inflammatory diseases and disorders, are provided herein. The compounds are collectively represented by Formulae Ia or Ib: wherein A, B D, E, G and R1-R5 are as defined in the specification.

  本文提供的化合物能够或可用于诱导癌细胞死亡和/或调节趋化因子的生物活性，如细胞迁移，和/或治疗与趋化因子的生物活性和/或细胞迁移相关的疾病和紊乱，和/或抑制激酶和/或治疗与激酶活性相关的疾病或紊乱，如癌症和炎症性疾病和紊乱。这些化合物统称为式 Ia 或式 Ib： 其中 A、B D、E、G 和 R1-R5 如说明书中所定义。
• [EN] SMALL MOLECULES FOR INHIBITING CHEMOKINE ACTIVITY, A KINASE ACTIVITY AND/OR CANCER CELLS GROWTH<br/>[FR] PETITES MOLÉCULES POUR INHIBER UNE ACTIVITÉ DE CHIMIOKINE, UNE ACTIVITÉ DE KINASE ET/OU LA CROISSANCE DES CELLULES CANCÉREUSES
  申请人：BIOKINE THERAPEUTICS LTD

  公开号：WO2017103932A9

  公开（公告）日：2017-08-24
• SMALL MOLECULES FOR INHIBITING CHEMOKINE ACTIVITY AND/OR CANCER CELLS GROWTH
  申请人：Biokine Therapeutics Ltd.

  公开号：EP3390364B1

  公开（公告）日：2020-07-15