4-(1H-Benzimidazol-2-ylmethoxy)-N'-((1E)-2-furylmethylene)benzohydrazide | 73418-63-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 4-(1H-Benzimidazol-2-ylmethoxy)-N'-((1E)-2-furylmethylene)benzohydrazide
• 英文别名: 4-(1H-benzimidazol-2-ylmethoxy)-N-[(E)-furan-2-ylmethylideneamino]benzamide
• CAS: 73418-63-0
• 化学式: C₂₀H₁₆N₄O₃
• 分子量: 360.4
• InChiKey: IIARSUCTPRZFNC-CIAFOILYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  92.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(1H-benzimidazol-2-yl)methyl phenoxy carboxylic acid hydrazide 、 糠醛 以7%的产率得到
  参考文献：
  名称：

  BAHADUR S.; PANDEY K. K., PHARMAZIE, 1979, 34, NO 9, 570

  摘要：

  DOI：

文献信息

• Oncostatin M (OSM) antagonists for preventing cancer metastasis and IL-6 related disorders
  申请人：Jorcyk Cheryl

  公开号：US10286070B2

  公开（公告）日：2019-05-14

  A method of treating cancer or metastasis is provided involving administering at least one oncostatin M (OSM) antagonist to a subject, wherein the subject has been diagnosed with cancer. Administration of an OSM antagonist such as a small molecule pharmaceutical is provided as well as an anti-OSM antibody, an anti-OSM aptamer, and an OSM mRNA antagonist. The OSM antagonists were found to inhibit or prevent tumor cell detachment, proliferation and metastasis in several cancer types.

  提供了一种治疗癌症或转移瘤的方法，该方法涉及对受试者施用至少一种OncOStatin M（OSM）拮抗剂，其中受试者已被诊断患有癌症。提供了一种 OSM 拮抗剂（如小分子药物）以及一种抗 OSM 抗体、一种抗 OSM 合酶和一种 OSM mRNA 拮抗剂。研究发现，OSM拮抗剂可抑制或防止几种癌症类型的肿瘤细胞脱落、增殖和转移。
• ONCOSTATIN M (OSM) ANTAGONISTS FOR PREVENTING CANCER METASTASIS AND IL-6 RELATED DISORDERS
  申请人：Jorcyk Cheryl

  公开号：US20170196973A1

  公开（公告）日：2017-07-13

  A method of treating cancer or metastasis is provided involving administering at least one oncostatin M (OSM) antagonist to a subject, wherein the subject has been diagnosed with cancer. Administration of an OSM antagonist such as a small molecule pharmaceutical is provided as well as an anti-OSM antibody, an anti-OSM aptamer, and an OSM mRNA antagonist. The OSM antagonists were found to inhibit or prevent tumor cell detachment, proliferation and metastasis in several cancer types.
• US9550828B2
  申请人：——

  公开号：US9550828B2

  公开（公告）日：2017-01-24