3-Hydroxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-one

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 3-Hydroxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-one
• 英文别名: 9-hydroxy-3-methyl-1,2,4,4a,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
• 化学式: C₁₇H₁₇NO₃
• 分子量: 283.32
• InChiKey: PFBSOANQDDTNGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• HPLC METHOD FOR SEPARATION AND DETECTION OF HYDROMORPHONE AND RELATED OPIOID PHARMACOPHORES
  申请人：Black Joshua P.L.

  公开号：US20080206883A1

  公开（公告）日：2008-08-28

  HPLC methods are provided to separate and detect morphinone, morphine, and dihydromorphine in the presence of hydromorphone. The isocratic HPLC methods employ ion-pair solute-solute ion-exchange mobile phase techniques in reversed phase chromatography. Method conditions in the disclosure provide separation and quantification of opioid pharmacophores in accordance with federal guidelines for obtaining resolution between analytes R≧2.0; tailing factor T≦2.0, capacity factor 2