2-methyl-N-(3-phenylpropyl)propanamide | 430452-95-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-N-(3-phenylpropyl)propanamide
• CAS: 430452-95-2
• 化学式: C₁₃H₁₉NO
• mdl: MFCD03138612
• 分子量: 205.3
• InChiKey: JTACLVOGBJULJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  异丙基氯化镁 、 N-(3-苯基丙基)氨基甲酸甲酯 以 四氢呋喃 为溶剂， 反应 24.17h， 以83%的产率得到2-methyl-N-(3-phenylpropyl)propanamide
  参考文献：
  名称：

  Amidation through carbamates

  摘要：

  N-Alkyl carbamates of primary amines are easily converted into amides under treatment with Grignard reagents. Consequently, primary amines call be converted into amides in a one-pot reaction through carbamate protection and Grignard addition. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.113

文献信息

• COMPOUNDS USEFUL FOR INHIBITING CHK1
  申请人：Keegan Kathleen S.

  公开号：US20100105683A1

  公开（公告）日：2010-04-29

  Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.

  本发明公开了用于治疗与DNA损伤或DNA复制中的损伤有关的疾病和病症的芳基和杂环基取代脲化合物。本发明还公开了制备该化合物的方法以及它们作为治疗剂的用途，例如，在治疗癌症和其他以DNA复制缺陷、染色体分离或细胞分裂为特征的疾病中。
• Aryl dihydropyridinones and piperidinone MGAT2 inhibitors
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10369140B2

  公开（公告）日：2019-08-06

  The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.

  本发明提供了式 (I) 的化合物： 或其立体异构体，或其药学上可接受的盐，其中所有变量如本文所定义。这些化合物是单酰基甘油酰基转移酶 2 型（MGAT2）抑制剂，可用作药物。
• ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20170216263A1

  公开（公告）日：2017-08-03

  The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
• US7608618B2
  申请人：——

  公开号：US7608618B2

  公开（公告）日：2009-10-27
• US9663466B2
  申请人：——

  公开号：US9663466B2

  公开（公告）日：2017-05-30