1-Oleoyl-2-acetoyl-sn-glycerol | 92282-11-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1-Oleoyl-2-acetoyl-sn-glycerol
• 英文别名: (2-acetyloxy-3-hydroxypropyl) octadec-9-enoate
• CAS: 92282-11-6
• 化学式: C₂₃H₄₂O₅
• 分子量: 398.6
• InChiKey: PWTCCMJTPHCGMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  28
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Therapeutic use of of acyglycerols and the nitrogen-and sulphur-containing analogues thereof
  申请人：Darteil Raphael

  公开号：US20060252827A1

  公开（公告）日：2006-11-09

  The invention relates to the use of acylglycerols and the nitrogen- and sulfur-containing analogues thereof in therapy, particularly for the treatment of cerebral ischemia. The invention further relates to methods for preparing said derivatives, novel compounds, in particular acylglycerols, the nitrogen- and sulfur-containing analogues thereof and methods for preparing same.

  这项发明涉及在治疗中使用酰基甘油和其氮和硫含量类似物，特别是用于治疗脑缺血。该发明还涉及制备这些衍生物的方法，新颖化合物，特别是酰基甘油，其氮和硫含量类似物以及制备它们的方法。
• [EN] TRPC5 INHIBITORS AND METHODS OF USING SAME<br/>[FR] INHIBITEURS DE TRPC5 ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV NEBRASKA

  公开号：WO2019051197A1

  公开（公告）日：2019-03-14

  Provided herein are TRPC5 inhibitors and methods of using the same, e.g., to protect podocytes and/or treat kidney disease.

  本文提供了TRPC5抑制剂及其使用方法，例如用于保护足细胞和/或治疗肾脏疾病。
• METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE
  申请人：Moazed Kambiz Thomas

  公开号：US20110280909A1

  公开（公告）日：2011-11-17

  Methods and systems are described for a rapid and sustainable change in the pigment melanin content of melanocytes of the iris stroma, thereby to change the color of the eye. Also described are nanoparticle compositions for lightening the pigmented tissues or treating a pigmented tissue related disease.

  描述了一种快速和可持续改变虹膜基质黑色素含量的黑色素细胞的方法和系统，从而改变眼睛的颜色。还描述了用于淡化有色组织或治疗有色组织相关疾病的纳米颗粒组合物。
• [EN] 5-LIPOXYGENASE ANTAGONISTS<br/>[FR] ANTAGONISTES DE 5-LIPOXYGÉNASE
  申请人：INST DE MEDICINA MOLECULAR

  公开号：WO2019050422A1

  公开（公告）日：2019-03-14

  This invention relates to the treatment of conditions, such as cancer, associated with 5-lipoxygenase (5-LO) expression using β-lapachone compounds that inhibit 5-lipoxygenase (5-LO), such as β- lapachone and derivatives thereof. Methods of treatment of conditions associated with 5-lipoxygenase (5-LO) expression as well as medical uses of β-lapachone compounds in such methods are provided, as well as methods of selecting or prognosing cancer patients.

  本发明涉及使用β-落花松醌化合物治疗与5-脂氧合酶（5-LO）表达相关的疾病，如癌症，这些化合物抑制5-脂氧合酶（5-LO），如β-落花松醌及其衍生物。提供了治疗与5-脂氧合酶（5-LO）表达相关的疾病的方法以及β-落花松醌化合物在这种方法中的医疗用途，以及选取或预测癌症患者的方法。
• [EN] NOVEL COMPOUND OF 6-METHYL-3-PHENETHYL-3,4-DIHYDRO-1H-QUINAZOLINE-2-THINONE, ITS PREPARATION AND A DEPIGMENTATION COMPOSITON CONTAINING THE SAME AS AN EFFECTIVE COMPONENT<br/>[FR] NOUVEAU COMPOSE DE 6-METHYL-3-PHENETHYL-3,4-DIHYDRO-1H-QUINAZOLINE-2-THINONE, SA PREPARATION ET COMPOSITION DE DEPIGMENTATION LE CONTENANT EN TANT QUE COMPOSANT ACTIF
  申请人：KIM YOUNGSOO

  公开号：WO2005016895A1

  公开（公告）日：2005-02-24

  The present invention relates to a novel compound of 6-methyl-3-phenethyl-3,4-dihydro-1H-quinazoline-2-thione represented by following formula (1), a preparation method thereof, a medicinal composition for prevention and treatment of hyperpigmentation comprising the same as an effective component, and a skin-whitening cosmetic composition comprising the same as an effective component :

  本发明涉及一种由以下式（1）所表示的6-甲基-3-苯乙基-3,4-二氢-1H-喹唑啉-2-硫醇的新化合物，其制备方法，以其为有效成分的预防和治疗色素沉着的药物组合物，以及以其为有效成分的美白化妆品组合物。