2-(methylamino)-N-phenethylbenzamide | 19050-63-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(methylamino)-N-phenethylbenzamide
• 英文别名: glycoamide A；glycoamide-A；2-(methylamino)-N-(2-phenylethyl)benzamide
• CAS: 19050-63-6
• 化学式: C₁₆H₁₈N₂O
• 分子量: 254.332
• InChiKey: QDLVHIXBWKCXDP-UHFFFAOYSA-N

物化性质

• 沸点：
  467.3±38.0 °C(Predicted)
• 密度：
  1.123±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  2-(methylamino)-N-phenethylbenzamide 在 tetraethylammonium hexafluorophosphate 作用下， 以 氘代甲醇 为溶剂， 反应 16.0h， 以75%的产率得到1-methyl-3-phenethyl-2,3-dihydroquinazolin-4(1H)-one-2,2-d₂
  参考文献：
  名称：

  Electrochemical utilization of methanol and methanol-d4 as a C1 source to access (deuterated) 2,3-dihydroquinazolin-4(1H)-one

  摘要：

  DOI：

  10.1016/j.cclet.2021.09.019
• 作为产物：
  描述：

  2-苯乙胺 在 无水氯化铜 、 乙酸乙酯 、 三乙胺 作用下， 以 甲醇 为溶剂， 反应 36.0h， 生成 2-(methylamino)-N-phenethylbenzamide
  参考文献：
  名称：

  Electrochemical utilization of methanol and methanol-d4 as a C1 source to access (deuterated) 2,3-dihydroquinazolin-4(1H)-one

  摘要：

  DOI：

  10.1016/j.cclet.2021.09.019

文献信息

• Syntheses of Quinazoline-2,4-dione Alkaloids and Analogues from Mexican Zanthoxylum Species †
  作者：I. Rivero、K. Espinoza、R. Somanathan

  DOI：10.3390/90700609

  日期：——

  Quinazolinone and quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties. In this paper we report the synthesis of ten quinazolinediones. The previous isolation of two of these compounds, namely 1-methyl-3-(2'-phenylethyl)-1H,3H-quinazoline-2,4-dione and 1-methyl-3-[2'-(4'- methoxyphenyl)ethyl]-lH,3H-quinazoline-2,4-dione, from the seed husks of Mexican Zanthoxylum species has been reported

  喹唑啉酮和喹唑啉二酮衍生物因其广泛的药理性质而受到广泛关注。在本文中，我们报告了十种喹唑啉二酮的合成。此前已经报道了其中两个化合物，即1-甲基-3-(2'-苯乙基)-1H,3H-喹唑啉-2,4-二酮和1-甲基-3-[2'-(4'-甲氧基苯基)乙基]-1H,3H-喹唑啉-2,4-二酮，来自墨西哥刺柠檬种子的种皮。
• A new scavenger resin for amines
  作者：Gary M. Coppola

  DOI：10.1016/s0040-4039(98)01778-x

  日期：1998.11

  Isatoic anhydride (1) can be attached to Merrifield resin by alkylation on its nitrogen. A maximum loading of 3.2 mmol of anhydride/g of 5 was achieved. This resin, due to the highly reactive anhydride moiety, completely removes primary and secondary aliphatic amines from reactions where they are used in excess.

  可以通过在其氮上进行烷基化将异酸酐（1）连接到Merrifield树脂上。达到3.2mmol酸酐/ g的最大负载量为5。由于高反应性酸酐部分，该树脂从过量使用伯胺和仲脂族胺的反应中完全去除了伯胺和仲脂族胺。
• Alkaloids of some Mexican Zanthoxylum species
  作者：David L. Dreyer、R.C. Brenner

  DOI：10.1016/0031-9422(80)85141-7

  日期：——

  Abstract Two new 4-quinazolone alkaloids have been isolated from seed husks of Zanthoxylum arborescens . Based on their spectroscopic properties they have been assigned structures, 1-methyl-3-(2′-phenylethyl)-1H,3H-quinazoline-2,4-dione and 1-methyl-3-[2′-(4″-methoxyphenyl)ethyl]-1H,3H-quinazoline-2,4-dione. These structural assignments have been confirmed by synthesis. Skimmianine has been obtained

  摘要 从花椒籽壳中分离得到两种新的4-喹唑酮类生物碱。根据它们的光谱特性，它们被指定为结构 1-methyl-3-(2'-phenylethyl)-1H,3H-quinazoline-2,4-dione 和 1-methyl-3-[2'-(4″-甲氧基苯基)乙基]-1H,3H-喹唑啉-2,4-二酮。这些结构分配已通过合成得到证实。Skimmianine 已从 Z. dimoncillo 和 Z. caribaeum 的叶提取物中获得，而skimmianine 和 scopeletin 已从 Z. fagara 的叶提取物中分离出来。
• Compounds that enhance Atoh-1 expression
  申请人：MASSACHUSETTS EYE & EAR INFIRMARY

  公开号：EP2732819A2

  公开（公告）日：2014-05-21

  This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g. a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

  本发明一般提供化合物、药物组合物及其使用方法，其中包括导致生物细胞中 Atoh1 基因（如 Hath1）表达增加的方法。更具体地说，本发明涉及可从 Atoh1 表达增加中获益的疾病和/或失调症的治疗，例如与听觉毛细胞丧失有关的听力损伤或失调症，或与细胞异常增殖有关的失调症。
• Compounds that enhance Atoh1 expression
  申请人：Massachusetts Eye & Ear Infirmary

  公开号：US10406163B2

  公开（公告）日：2019-09-10

  This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

  本发明一般提供化合物、药物组合物及其使用方法，其中包括导致生物细胞中Atoh1基因（如Hath1）表达增加的方法。更具体地说，本发明涉及可从 Atoh1 表达增加中获益的疾病和/或失调症的治疗，例如，与听觉毛细胞丧失有关的听力损伤或失调症，或与细胞异常增殖有关的失调症。