1-(3-Ethoxy-4-hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 1-(3-Ethoxy-4-hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
• 化学式: C₂₂H₂₂O₆
• 分子量: 382.4
• InChiKey: QCWGBELNDNDQLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Compositions and methods for the treatment of allergic rhinitis
  申请人：Ram Sunder A.N.

  公开号：US20060275516A1

  公开（公告）日：2006-12-07

  The invention concerns novel pharmaceutical compositions and methods for the treatment of allergic rhinitis. More specifically, the invention concerns the inhibition of histamines, which is one of the primary causes of allergic rhinitis in human patients. The inventive pharmaceutical compositions include a carbonyl group-containing moiety, optionally in acidic medium, that combines with histamine to block histamine activity and thus reduce undesirable physiological effects of histamine in the body.

  本发明涉及一种新型药物组合物和治疗过敏性鼻炎的方法。更具体地说，本发明涉及抑制组胺的方法，组胺是人类患者过敏性鼻炎的主要原因之一。该创新性的药物组合物包括含有羰基基团的基团，可选地在酸性介质中，与组胺结合以阻止组胺活性，从而减少组胺在体内的不良生理效应。
• Novel curcumin analogues and uses thereof
  申请人：——

  公开号：US20030203933A1

  公开（公告）日：2003-10-30

  The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.

  本发明涉及一种能够作为雄激素受体拮抗剂的化合物、包含该化合物的药物配方以及使用它们的方法。这些用途包括但不限于作为抗肿瘤剂，特别是用于治疗结肠癌、皮肤癌和前列腺癌等癌症，并在患有与雄激素相关的疾病的受试者中诱导雄激素受体拮抗剂活性。雄激素相关疾病的例子包括但不限于脱发、多毛症、行为障碍、痤疮和无抑制的精子生成，其中需要抑制精子生成。
• NOVEL CURCUMIN ANALOGUES AND USES THEREOF
  申请人：Lee Kuo-Hsiung

  公开号：US20080161391A1

  公开（公告）日：2008-07-03

  The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.

  本发明涉及能够作为雄激素受体拮抗剂的化合物、含有该化合物的制药配方以及其使用方法。这些用途包括但不限于作为抗肿瘤剂，特别是用于治疗结肠癌、皮肤癌和前列腺癌等癌症，以及在患有雄激素相关疾病的人体内诱导雄激素受体拮抗活性。雄激素相关疾病的例子包括但不限于脱发、多毛症、行为障碍、痤疮以及需要抑制精子生成的不受抑制的精子生成。
• Shunt delivery of curcumin for the treatment Alzneimer
  申请人：Codman & Shurtleff, Inc.

  公开号：EP2359820A1

  公开（公告）日：2011-08-24

  A method for reducing or preventing a human brain disorder relating to the presence of a pathogenic substance in cerebrospinal fluid by selecting a human for treatment as a patient and placing a proximal end of a first catheter, having at least a first lumen, in a first sub-dural location within the brain of the patient to establish open communication between the first lumen and cerebrospinal fluid of the patient. For an extended period of time, a curcumin agent selected from at least one of curcumin, a curcumin hybrid and a curcumin analog is delivered to the cerebrospinal fluid to interact with the pathogenic substance to attenuate its effect on the brain.

  一种减少或预防与脑脊液中存在致病物质有关的人类脑部疾病的方法，其方法是选择人类作为患者进行治疗，并将具有至少第一管腔的第一导管的近端置于患者脑内的第一硬膜下位置，以建立第一管腔与患者脑脊液之间的开放式交流。在一段较长的时间内，选自姜黄素、姜黄素混合物和姜黄素类似物中至少一种的姜黄素制剂被输送到脑脊液中，与致病物质相互作用，以减弱其对大脑的影响。
• Curcumin-resveratrol hybrids
  申请人：Codman & Shurtleff, Inc.

  公开号：EP2749552A1

  公开（公告）日：2014-07-02

  Novel molecules based upon hybridization of curcumin and hydroxystilbenes, such as resveratrol. It is believed that these novel molecules will have special application in treating Alzheimer's disease.

  基于姜黄素和羟基二苯乙烯（如白藜芦醇）杂交的新型分子。相信这些新型分子在治疗阿尔茨海默氏症方面会有特殊用途。