Homatropin-hydrochlorid | 637-21-8

• 物质功能分类: 天然产物 - 生物碱
• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: Homatropin-hydrochlorid
• 英文别名: hydron;(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;chloride
• CAS: 637-21-8
• 化学式: C₁₆H₂₁NO₃*ClH
• 分子量: 311.809
• InChiKey: FRMDDIJBLQNNTC-UHFFFAOYSA-N

物化性质

• 熔点：
  226 °C
• 溶解度：
  碱性溶液（微溶）、甲醇（微溶）、水（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  2.31
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  49.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险等级：
  6.1
• 海关编码：
  2933990090

文献信息

• AMORPHOUS BIOINORGANIC IONIC LIQUID COMPOSITIONS COMPRISING AGRICULTURAL SUBSTANCES
  申请人：LOS ALAMOS NATIONAL SECURITY, LLC

  公开号：US20130252818A1

  公开（公告）日：2013-09-26

  An amorphous formulation of a herbicidal or pesticidal substance includes a composition of the formula [A] x [M p Cl q ] y , the composition being an ionic liquid with a melting temperature below 150° C., wherein [M p Cl q ] is a metal chloride, x is 1, 2, 3, or 4, p is 1, 2, 3, or 4, q is 1, 2, 3, 4, 5, 6, 7, 8, or 9, and y is 1 or 2, wherein each A is a cation that is a herbicidal or pesticidal substance or a cation precursor that is a herbicidal or pesticidal substance.

  一种除草剂或杀虫剂物质的无定形配方包括公式[A]x[MpClq]y的组合物，该组合物是一种熔点低于150°C的离子液体，其中[MpClq]是金属氯化物，x为1、2、3或4，p为1、2、3或4，q为1、2、3、4、5、6、7、8或9，y为1或2，其中每个A是一种除草剂或杀虫剂物质或一种除草剂或杀虫剂物质的阳离子前体。
• [EN] MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE<br/>[FR] COMPOSÉS DE LACTONE MACROCYCLIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ELIXIR MEDICAL CORP

  公开号：WO2009114010A1

  公开（公告）日：2009-09-17

  The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula (I) wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, -OH, -OP(O)Me2, (II), (III), -O-(CH2)n-OH and -O-(CH2)m-O-(CH2)o-CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of (IV) and (V) wherein each M8 is independently a member selected from the group consisting Of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of (VI), (VII) and (VIII); and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.

  本发明提供了一种制药组合物，该组合物包括一种药用可接受的赋形剂和一种式(I)的化合物，其中R1、R2、R3、R5、R6、R8、M1、M2、M3、M4、M5、M6和M7各自独立地选择自H、C1-6烷基、OH和C1-6羟基烷基的群体中的一种；R4、R7和R9各自独立地选择自C1-6烷氧基和OH的群体中的一种；R10选择自H、-OH、-OP(O)Me2、(II)、(III)、-O-(CH2)n-OH和-O-( )m-O-( )o-CH3的群体中的一种，其中下标n和m各自独立地从2到8，下标o从1到6；L1和L4各自独立地选择自(VI)和(VII)的群体中的一种，其中每个M8各自独立地选择自C1-6烷基、OH和C1-6羟基烷基的群体中的一种；L2和L3各自独立地选择自(VI)、(VII)和(VIII)的群体中的一种；以及其盐、水合物、异构体、代谢物、N-氧化物和前药。
• Osmotic drug delivery device
  申请人：Merck & Co., Inc.

  公开号：EP0180708A1

  公开（公告）日：1986-05-14

  An osmotic drug (or other beneficial substance) delivery device comprises a compartment with a chamber formed by an external shell (2) of a microporous material, and an overlayer of a semipermeable membrane (1) substantially covering the outer shell (2) of the chamber. Osmotic agents, adjuvants enzymes, drugs, pro-drugs, pesticides and the like are incorporated in the chamber covered by the semipermeable membrane, and external fluids that diffuse into this chamber form solutions and by osmotic pressure are forced through the exposed microporous shell (2) to the exterior of the device at a rate controlled by the permeability of the semipermeable overlay and the osmotic pressure gradient across the shell.

  一种渗透性药物（或其他有益物质）输送装置包括一个带有由微孔材料外壳（2）形成的腔室的隔室，以及基本上覆盖腔室外壳（2）的半透膜（1）覆盖层。 渗透剂、佐剂酶、药物、原药、杀虫剂等被加入到由半透膜覆盖的腔室中，扩散到该腔室中的外部流体形成溶液，并在渗透压的作用下被迫穿过暴露的微孔外壳（2）到达装置外部，其速率由半透膜覆盖层的渗透性和外壳上的渗透压梯度控制。
• Skin penetration system for salts of amine-functional drugs
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0351897A2

  公开（公告）日：1990-01-24

  The invention involves pharmaceutical compositions for topical application comprising: (a) a pharmaceutically-acceptable salt of addition of an amine-functional drug (other than opioid analgesic drugs); (b) a C₇ to C₂₂ straight-chain or branched-chain, saturated or unsaturated, fatty acid having a melting point of less than about 50°C; and (c) a C₃-C₄ alkane diol.

  本发明涉及用于局部应用的药物组合物，包括 (a) 一种胺功能药物（阿片类镇痛药除外）的药学上可接受的加成盐； (b) C₇ 至 C₂₂ 直链或支链、饱和或不饱和脂肪酸，熔点低于约 50°C；以及 (c) C₃-C₄ 烷二醇。
• Macrocyclic lactone compounds and methods for their use
  申请人：Elixir Medical Corporation

  公开号：US10123996B2

  公开（公告）日：2018-11-13

  A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of: and salts, isomers, or N-oxides thereof.

  一种药物组合物，包含一种药学上可接受的赋形剂和一种式化合物： 其中 R1、R2、R3、R5、R6、R8、M1、M2、M3、M4、M5、M6 和 M7 各自独立地选自由 H、C1-6 烷基、OH 和 C1-6 羟烷基组成的组；R4、R7 和 R9 各自独立地选自由 C1-6 烷氧基和 OH 组成的组；R10 选自由 H、-OH、-OP(O)Me2 组成的组、 -O-(CH2)n-OH和-O-( )m-O-( )o-CH3，其中下标n和m各自独立地为2至8，下标o为1至6；L1和L4各自独立地选自由以下组成的组： 其中每个 M8 独立地是选自由 C1-6 烷基、OH 和 C1-6 羟基烷基组成的组的成员；每个 L2 和 L3 独立地是选自由以下组成的组的成员： 和 及其盐类、异构体或 N-氧化物。

表征谱图