3-(1-Methoxyhexadecoxy)propane-1,2-diol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 3-(1-Methoxyhexadecoxy)propane-1,2-diol
• 英文别名: 3-(1-methoxyhexadecoxy)propane-1,2-diol
• 化学式: C₂₀H₄₂O₄
• 分子量: 346.5
• InChiKey: RWTDXNLHQUZQFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  24
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] MULTIMERIC MANNOSIDES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG<br/>[FR] MANNOSIDES MULTIMÉRIQUES, UN PROCÉDÉ DE PRÉPARATION DE CEUX-CI ET LEURS UTILISATIONS EN TANT QUE MÉDICAMENT
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2014016361A1

  公开（公告）日：2014-01-30

  The present invention relates to multimeric mannosides, a process for preparing the same and their uses in medicine for treating Escherichia Coli infections. Exemplary compounds are:

  本发明涉及多聚甘露糖苷，其制备方法以及它们在医药中用于治疗大肠杆菌感染的用途。典型的化合物包括：
• [EN] FENTANYL HAPTENS, FENTANYL HAPTEN CONJUGATES, AND METHODS FOR MAKING AND USING<br/>[FR] HAPTÈNES DE FENTANYL, CONJUGUÉS D'HAPTÈNE DE FENTANYL, ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：UNIV MINNESOTA

  公开号：WO2021183913A1

  公开（公告）日：2021-09-16

  This disclosure describes fentanyl haptens, a fentanyl hapten-carrier conjugate, methods of making the fentanyl hapten-carrier conjugate, and methods of using the fentanyl hapten-carrier conjugate including, for example, as a prophylactic vaccine to counteract toxicity from exposure to fentanyl, fentanyl derivatives, and fentanyl analogs. In some embodiments, the fentanyl hapten-carrier conjugate or a composition including the fentanyl hapten-carrier conjugate may be used in an anti-opioid vaccine.

  这份披露描述了芬太尼半抗原、芬太尼半抗原载体共轭物，制备芬太尼半抗原载体共轭物的方法，以及使用芬太尼半抗原载体共轭物的方法，例如作为一种预防性疫苗来对抗暴露于芬太尼、芬太尼衍生物和芬太尼类似物所产生的毒性。在某些实施方式中，芬太尼半抗原载体共轭物或包含芬太尼半抗原载体共轭物的组合物可用作抗阿片类药物的疫苗。
• Mannose derivatives, a process for preparing the same and their uses as a drug
  申请人：Centre National de la Recherche Scientifique

  公开号：EP2690105A1

  公开（公告）日：2014-01-29

  The present invention relates to heptyl α-D mannoside clusters for use in the treatment of diseases caused by bacterium Escherichia coli. Representative compounds are those below :

  本发明涉及庚基α-D甘露聚糖簇的用途，用于治疗由大肠埃希菌引起的疾病。代表性化合物如下：
• Npcil1 (Npc3) And Methods Of Identifying Ligands Thereof
  申请人：Garcia-Calvo Maria Margarita

  公开号：US20100009461A1

  公开（公告）日：2010-01-14

  The present invention provides human, rat and mouse NPCIL1 polypeptides and polynucleotides encoding the polypeptides. Methods for detecting ligands which bind to NPC1L1 and block intestinal cholesterol absorption are provided. Also included is a method of identifying ligands which bind to NPCILI using membranes derived from brush border membrane preparations. Compounds that bind to NPCILI can be used for inhibiting intestinal cholesterol absorption in a subject.

  本发明提供人、大鼠和小鼠NPCIL1多肽和编码该多肽的多核苷酸。提供检测与NPC1L1结合并阻止肠道胆固醇吸收的配体的方法。还包括使用来自刷状缘膜制备的膜鉴定与NPCILI结合的配体的方法。与NPCILI结合的化合物可用于抑制受试者的肠道胆固醇吸收。
• Production of herpes simplex viral proteins
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0101655A2

  公开（公告）日：1984-02-29

  Methods and compositions are provided for the cloning and expression of Herpes Simplex Virus (HSV type 1 or type 2) glycoprotein (gD) gene in single-cell host organisms. Also described are methods for culturing these novel single-cell organisms to produce HSV-gene products. The HSV gD-related polypeptides produced by the recombinant DNA techniques described herein may be formulated for use as immunogens in vaccines to protect against HSV-1 and HSV-2 infections.

  提供了在单细胞宿主生物体中克隆和表达单纯疱疹病毒（HSV 1 型或 2 型）糖蛋白（gD）基因的方法和组合物。还描述了培养这些新型单细胞生物以生产 HSV 基因产品的方法。通过本文所述的 DNA 重组技术生产的 HSV gD 相关多肽可配制成疫苗中的免疫原，用于预防 HSV-1 和 HSV-2 感染。