5,8-dihydroxy-1-tetralone | 1077-69-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 5,8-dihydroxy-1-tetralone
• 英文别名: 5,8-Dihydroxy-<1>tetralon；5,8-Dihydroxy-tetralon-(1)；5,8-Dihydroxy-1-oxo-1,2,3,4-tetrahydro-naphthalin；5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one；5,8-Dihydroxy-3,4-dihydro-2H-naphthalin-1-on；5,8-Dihydroxy-3,4-dihydro-1(2H)-naphthalenone；5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one
• CAS: 1077-69-6
• 化学式: C₁₀H₁₀O₃
• mdl: MFCD04037515
• 分子量: 178.188
• InChiKey: RXOWVXQQENEZMJ-UHFFFAOYSA-N

物化性质

• 熔点：
  184 °C
• 沸点：
  416.3±45.0 °C(Predicted)
• 密度：
  1.374±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5,8-dihydroxy-1-tetralone 在 三氯化铁 、 溶剂黄146 作用下， 生成 5-羟基对萘醌
  参考文献：
  名称：

  Shoji, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1959, vol. 79, p. 1038

  摘要：

  DOI：
• 作为产物：
  描述：

  5,8-二甲氧基-1-四氢萘酮 在 三氯化铝 作用下， 生成 5,8-dihydroxy-1-tetralone
  参考文献：
  名称：

  335.减少juglone

  摘要：

  DOI：

  10.1039/jr9520001822

文献信息

• Furan Derivatives. IV. On the Effects of Substituents in the Syntheses of 4,5-Dihydro-3<i>H</i>-naphtho[1,8-<i>bc</i>]furans
  作者：Sakaaki Horaguchi、Mamoru Hara、Tsuneo Suzuki

  DOI：10.1246/bcsj.55.865

  日期：1982.3

  The reaction of (8-oxo-5,6,7,8-tetrahydro-1-naphthyloxy)acetic acids with acetic anhydride and sodium acetate give a mixture of 4,5-dihydro-3H-naphtho[1,8-bc]furans and lactones. The relative yields of 4,5-dihydro-3H-naphtho[1,8-bc]furans and lactones varied according to kinds of substituents on the benzene ring of (8-oxo-5,6,7,8-tetrahydro-1-naphthyloxy)acetic acids. Substituents which make the methylene

  (8-oxo-5,6,7,8-tetrahydro-1-naphthyloxy) 乙酸与乙酸酐和乙酸钠反应得到 4,5-dihydro-3H-naphtho[1,8-bc] 的混合物呋喃和内酯。4,5-二氢-3H-萘并[1,8-bc]呋喃和内酯的相对产率因(8-oxo-5,6,7,8-tetrahydro-1 -萘氧基)乙酸。通过空间效应使亚甲基更接近 (8-oxo-5,6,7,8-tetrahydro-1-naphthyloxy) 乙酸的羰基碳原子的取代基似乎有利于 4,5-dihydro -3H-萘并[1,8-bc]呋喃。另一方面，使亚甲基与羰基碳原子分离的取代基似乎有利于内酯的产生。(8-oxo-5,6,7,
• Utility of Nitrogen Extrusion of Azido Complexes for the Synthesis of Nitriles, Benzoxazoles, and Benzisoxazoles
  作者：Phongprapan Nimnual、Jumreang Tummatorn、Charnsak Thongsornkleeb、Somsak Ruchirawat

  DOI：10.1021/acs.joc.5b01305

  日期：2015.9.4

  The utility of the nitrogen extrusion reaction of azido complexes, generated in situ from the corresponding aldehydes or ketones with TMSN3 in the presence of ZrCl4 or TfOH, has been described. These azido complexes could undergo three different pathways, depending on the substrates. First, azido methanolate complexes or imine diazonium ions could lead to benzisoxazole products via an intramolecular nucleophilic substitution. Second, imine diazonium ions could also undergo either the elimination of proton to provide nitrile products in good to excellent yields or an aryl migration, followed by an intramolecular nucleophilic addition, to give benzoxazole products in good yields.
• Hydroxylation du benzaldehyde et de cetones aromatiques par le peroxyde d'hydrogene en milieu superacide
  作者：Jean-Pierre Gesson、Jean-Claude Jacquesy、Marie-Paule Jouannetaud、Guy Morellet

  DOI：10.1016/s0040-4039(00)88104-6

  日期：1983.1
• Momose et al., Pharmaceutical Bulletin, 1954, vol. 2, p. 119,122
  作者：Momose et al.

  DOI：——

  日期：——
• Derivatives of 3,4-dihydro-1(2H)-naphthalenone as .beta.-adrenergic blocking agents. 2. Aromatic-substituted analogs of bunolol
  作者：Charles F. Schwender、Russell E. Pike、John Shavel

  DOI：10.1021/jm00261a020

  日期：1973.3