2-Bromo-4-[(3-bromo-4-hydroxyphenyl)methyl]phenol | 1009647-11-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Bromo-4-[(3-bromo-4-hydroxyphenyl)methyl]phenol
• CAS: 1009647-11-3
• 化学式: C₁₃H₁₀Br₂O₂
• 分子量: 358.029
• InChiKey: SGQHSBDQMLESDM-UHFFFAOYSA-N

物化性质

• 沸点：
  429.4±40.0 °C(Predicted)
• 密度：
  1.807±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4,4'-二羟基二苯甲烷 在 溴 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 2-Bromo-4-[(3-bromo-4-hydroxyphenyl)methyl]phenol 、 2,6-Dibromo-4-[(3-bromo-4-hydroxyphenyl)methyl]phenol
  参考文献：
  名称：

  Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives

  摘要：

  A series of bromophenols was obtained by isolation from red alga Odonthalia corymbifera and by reactions of bis(hydroxyphenyl)methanes with bromine. New bromophenols including 3,3,5,5'-tetrabromo-2,2',4,4'-tetrahydroxydiphenylmethane (10), a regioisomer of the potent antimicrobial natural product, together with known derivatives were synthesized in high yield. All of the isolated and synthesized compounds were tested for antimicrobial activity against Gram-negative, Gram-positive bacteria and fungi. The preliminary structure-activity relationship, to elucidate the essential structure requirements for antimicrobial activity, has been described. Among the isolated natural products 2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane (4) was found to be the most active derivative against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum, and Trichophyton mentagrophytes. The synthetic bromophenols 3,3'-dibromo-6,6'-dihydroxydiphenylmethane (13) and 3,3',5,5'-tetrabromo-6, 6'-dihydroxydiphenylmethane (14) showed potent antibacterial effect against Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus. Proteus vulgaris, and Salmonella typhimurium. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.003

文献信息

• Glasfaserverstärkte thermoplastische Formmassen auf der Basis von Polyestern und Pfropfpolymerisaten
  申请人：BASF Aktiengesellschaft

  公开号：EP0310956A2

  公开（公告）日：1989-04-12

  Thermoplastische Formmassen auf der Basis von thermoplastischen Polyestern (a₁), Pfropfpolymerisaten mit Acrylatkautschuken als Pfropfgrundlage, Copolymeren aus vinylaromatischen Monomeren und Acrylnitril oder Meth­acrylnitril, einer Flammschutzmittelkombination aus halogenhaltigem Oligo- oder Polycarbonat oder Polyepoxid (b₁) und einer synergistischen Metallverbindung (b₂) sowie Glasfasern (C) weisen neben einem guten Brand­schutz auch ausgezeichnete mechanische Eigenschaften auf.

  基于热塑性聚酯（a₁）的热塑性模塑料、以丙烯酸酯橡胶为接枝基的接枝聚合物、乙烯基芳香族单体与丙烯腈或甲基丙烯腈的共聚物、卤化低聚或聚碳酸酯或聚环氧化物（b₁）和增效金属化合物（b₂）的阻燃组合以及玻璃纤维（C）具有良好的防火性能和优异的机械性能。
• Halogenated copolycarbonates having improved end group selectivity and resistance to degradation
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0441369A2

  公开（公告）日：1991-08-14

  A halogenated copolycarbonate, which contains reduced levels of Phenolic (-OH) End Groups and end groups which result from side reactions of process chemicals with the copolycarbonate chain (Process Chemical End Groups), has improved resistance to the degradation-inducing effects of such end groups and has improved washability. Such a halogenated copolycarbonate is characterized in that it (a) has a Phenolic End Group content of less than 275 ppm, (b) has a content of less than 90 ppm of the element of Process Chemical End Groups which is bonded to a copolycarbonate chain end, and (c) produces less than 0.5 absorbance units, per mole fraction of halogenated diphenol in the copolycarbonate, when measured on a spectrophotometer at 420 nm after the halogenated copolycarbonate has been heated for thirty minutes at 300°C and then dissolved in an organic solvent.

  卤代共聚碳酸酯含有较少的酚醛（-OH）末端基和加工化学品与共聚碳酸酯链（加工化学品末端基）发生副反应而产生的末端基（加工化学品末端基），具有更强的抗此类末端基诱导降解作用的能力，并具有更好的耐洗性。这种卤代共聚碳酸酯的特点是：(a) 酚端基含量小于 275 ppm；(b) 与共聚碳酸酯链端键合的工 艺化学端基元素含量小于 90 ppm；(c) 每摩尔分数产生的吸光度小于 0.(c) 卤化共聚碳酸酯在 300°C 下加热三十分钟，然后溶解在有机溶剂中，用分光光度计在 420 纳米波长处测量，共聚碳酸酯中每摩尔分数卤化二苯酚产生的吸光度单位小于 0.5。
• Flame retardant composition of polyerstercarbonate, halogenated polycarbonate, potassium diphenylsulfone sulfonate and polytetrafluoroethylene
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0838503A1

  公开（公告）日：1998-04-29

  A polyestercarbonate copolymer blend which exhibits a glass transition temperature lower than bisphenol-A carbonate homopolymer, shows good processability and fire-retardancy. The desired lower Tg and improved flow can be achieved by the polycondensation of a dihydric phenol and aliphatic dicarboxylic acid. The condensate is polymerized with a carbonate forming reagent. The resin is fire-retarded with a mixture of halogenated polycarbonate, potassium diphenylsulfone sulfonate and polytetrafluoroethylene.

  一种聚酯碳酸酯共聚物混合物的玻璃化转变温度低于双酚 A 碳酸酯均聚物，具有良好的加工性和阻燃性。通过二元苯酚和脂肪族二羧酸的缩聚，可以达到所需的较低 Tg 值并改善流动性。缩合物与碳酸盐形成试剂聚合。用卤化聚碳酸酯、二苯基砜磺酸钾和聚四氟乙烯的混合物对树脂进行阻燃处理。
• Ionizing-radiation-resistant polycarbonate resin composition, and molded product comprising same
  申请人：LOTTE ADVANCED MATERIALS CO., LTD.

  公开号：US10557034B2

  公开（公告）日：2020-02-11

  A polycarbonate resin composition of the present invention comprises: a polycarbonate resin; a polyalkylene glycol; an epoxy ester compound containing an ester group and an epoxy group; and a halogenated polycarbonate oligomer. The polycarbonate resin composition has excellent discoloration resistance, color, hydrolysis resistance, flame retardancy and the like even after being irradiated with ionizing radiation.

  本发明的聚碳酸酯树脂组合物包括：聚碳酸酯树脂；聚亚烷基二醇；含有酯基和环氧基的环氧酯化合物；以及卤代聚碳酸酯低聚物。这种聚碳酸酯树脂组合物即使在电离辐射照射下也具有优异的抗变色性、色泽、抗水解性和阻燃性等。
• Thermoplastic resin composition
  申请人：——

  公开号：US20010034419A1

  公开（公告）日：2001-10-25

  A thermoplastic resin composition comprising: a transparent aromatic thermoplastic resin (a) and a copolyester resin (b) comprising at least two kinds of dicarboxylic acid moieties and one kind of diol moiety, 1 to 50 mol % of the dicarboxylic acid moieties being a naphthalenedicarboxylic acid moiety, the ratio of (a) to the combined amount of (a) and (b) being 55 to 99.99% by weight, and the ratio of (b) being 0.01 to 45% by weight.

  一种热塑性树脂组合物，包括 透明芳香族热塑性树脂（a）和 由至少两种二羧酸分子和一种二元醇分子组成的共聚酯树脂（b），其中 1 至 50 摩尔%的二羧酸分子为萘二甲酸分子、 按重量计，(a)与(a)和(b)的总和之比为 55%至 99.99%，(b)之比为 0.01%至 45%。